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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
FT4 levels on tests and brain fog
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<blockquote data-quote="JoeMatts" data-source="post: 192146" data-attributes="member: 41444"><p>Prolactin is very elevated, but it's always in-response to testosterone and hcg, so it's primarily mediated by an increased is systemic estrogenic load.</p><p></p><p>You are correct that thyroid and adrenals are hard to treat in terms of practicality, but that doesn't bother me too much because impaired thyroid function is heavily implicated in heart disease, cancer, various brain diseases, etc, so treatment goes well beyond just feeling better. Thyroid itself is straightforward - start small, increase dose every two to four weeks using basal body temperature, symptoms and labs as barometers - but the main issues arise when the adrenal response does not rise accordingly to support an increased metabolic rate.</p><p></p><p>Theoretically thyroid + pregnenolone and/or progesterone should fill the need for hydrocortisone, but you can definitely use low doses without risk of long-term suppression. Regardless, the implications of HPTA shutdown are much more serious than that of the HPTA, so it's not worth messing with unless the adrenals are destroyed imo (which mine aren't; I had a strong adrenal response to 250mcg tetracosactrin). Also, supplemental cortisol covers up the symptoms but does nothing to address the underlying reason as to why cortisol is low, which is another downside to consider.</p><p></p><p>Have never and would never touch any substance that directly increases serotonin, including SSRI's, but also 5-HTP, l-trypophan, certain herbs, etc. There's little evidence to support the 'happy hormone' label big pharma has placed on serotonin, whereas there's an abundance of data to support the opposite — the fact that it increases alongside estrogen, prolactin, cortisol, and other mediators of the stress system is telling. Interesting read for those interested:</p><p></p><p><a href="https://pubmed.ncbi.nlm.nih.gov/25625874/" target="_blank">Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response</a></p></blockquote><p></p>
[QUOTE="JoeMatts, post: 192146, member: 41444"] Prolactin is very elevated, but it's always in-response to testosterone and hcg, so it's primarily mediated by an increased is systemic estrogenic load. You are correct that thyroid and adrenals are hard to treat in terms of practicality, but that doesn't bother me too much because impaired thyroid function is heavily implicated in heart disease, cancer, various brain diseases, etc, so treatment goes well beyond just feeling better. Thyroid itself is straightforward - start small, increase dose every two to four weeks using basal body temperature, symptoms and labs as barometers - but the main issues arise when the adrenal response does not rise accordingly to support an increased metabolic rate. Theoretically thyroid + pregnenolone and/or progesterone should fill the need for hydrocortisone, but you can definitely use low doses without risk of long-term suppression. Regardless, the implications of HPTA shutdown are much more serious than that of the HPTA, so it's not worth messing with unless the adrenals are destroyed imo (which mine aren't; I had a strong adrenal response to 250mcg tetracosactrin). Also, supplemental cortisol covers up the symptoms but does nothing to address the underlying reason as to why cortisol is low, which is another downside to consider. Have never and would never touch any substance that directly increases serotonin, including SSRI's, but also 5-HTP, l-trypophan, certain herbs, etc. There's little evidence to support the 'happy hormone' label big pharma has placed on serotonin, whereas there's an abundance of data to support the opposite — the fact that it increases alongside estrogen, prolactin, cortisol, and other mediators of the stress system is telling. Interesting read for those interested: [URL='https://pubmed.ncbi.nlm.nih.gov/25625874/']Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response[/URL] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
FT4 levels on tests and brain fog
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