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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
FT4 levels on tests and brain fog
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<blockquote data-quote="JoeMatts" data-source="post: 192133" data-attributes="member: 41444"><p>The trt-induced adrenal suppression involved below range serum am cortisol, low four-point saliva cortisol across the day, undetectable progesterone and below-range DHEA-S — all of which return to normal following the cessation of testosterone. Taking thyroid hormone has a similar suppressive effect though not as severe, so it might not be solely related to testosterone (I believe testosterone's suppressive effect on both the release and action of ACTH is heavily involved, however).</p><p></p><p>Anecdotally, 2.5 - 5 mg of hydrocortisone upon waking causes the fatigue to immediately dissipate, but hydrocortisone supplementation isn't something I'm interested in pursuing long-term.</p><p></p><p>Consider testing total T4 and T3 instead of free, as they always better correlated with my symptoms; the 'free hormone' hypothesis has various flaws.</p></blockquote><p></p>
[QUOTE="JoeMatts, post: 192133, member: 41444"] The trt-induced adrenal suppression involved below range serum am cortisol, low four-point saliva cortisol across the day, undetectable progesterone and below-range DHEA-S — all of which return to normal following the cessation of testosterone. Taking thyroid hormone has a similar suppressive effect though not as severe, so it might not be solely related to testosterone (I believe testosterone's suppressive effect on both the release and action of ACTH is heavily involved, however). Anecdotally, 2.5 - 5 mg of hydrocortisone upon waking causes the fatigue to immediately dissipate, but hydrocortisone supplementation isn't something I'm interested in pursuing long-term. Consider testing total T4 and T3 instead of free, as they always better correlated with my symptoms; the 'free hormone' hypothesis has various flaws. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
FT4 levels on tests and brain fog
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