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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
FT4 levels on tests and brain fog
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<blockquote data-quote="JoeMatts" data-source="post: 192075" data-attributes="member: 41444"><p>Anecdotally, my hypothyroid symptoms - low body temps and pulse, fatigue, dry skin, digestive issues, etc - have always correlated with my fT4 and total T4, even when fT3 was top of the range, and TSH was within range, but slightly elevated. These symptoms started following an extended period of severe caloric restriction, prolonged fasting and excessive exercise — all of which are suppressive to thyroid function on various levels.</p><p></p><p>TSH directly stimulates D2 deiodinase which controls T4 -> T3 conversion. As overall output from the thyroid begins to decline, the pituitary can compensate by increasing TSH production to not only direct increased thyroid hormone output, but also to maintain circulating T3 by increasing D2 activity, and thus peripheral T4 -> T3 conversion. This situation may manifest as moderate-high fT3, but a barely in-range fT4 and total T4, with a slightly elevated TSH between 2.5 - 4. However, although circulating T3 levels are maintained, there are various cells which rely solely on the uptake of T4 for local conversion to T3 rather than the direct uptake of T3 itself, which is why maintaining an optimal total and fT4 is extremely important, despite T4 itself being a largely inactive hormone — this is especially true for cells in the CNS, as T4 crosses the blood-brain-barrier more readily than T3; google 'hyperthyroid dementia' which can result from high-dose T3 monotherapy suppressing systemic T4 levels for more information.</p><p></p><p>My own thyroid panel has always fit the above, and my body temps, heart rate and other hypothyroid symptoms respond strongly to taking thyroid hormone, despite all my labs being within range, and fT3 being 'optimal'. Unfortunately, I struggle to tolerate thyroid hormone long-term as it causes my cortisol to drop below range which produces extremely severe symptoms, and subsequently the forced cessation of treatment. Low cortisol is often associated with hypothryoidism as the adrenals themselves require adequate thyroid hormone for cholesterol -> pregnenolone conversion, and thus the production of their own hormones.</p><p></p><p>I'm hoping some combination of thyroid + hydrocortisone and/or pregnenolone and/or progesterone will allow me to make progress in addressing my hypothyroid symptoms, but there is still a lot of experimentation needed.</p></blockquote><p></p>
[QUOTE="JoeMatts, post: 192075, member: 41444"] Anecdotally, my hypothyroid symptoms - low body temps and pulse, fatigue, dry skin, digestive issues, etc - have always correlated with my fT4 and total T4, even when fT3 was top of the range, and TSH was within range, but slightly elevated. These symptoms started following an extended period of severe caloric restriction, prolonged fasting and excessive exercise — all of which are suppressive to thyroid function on various levels. TSH directly stimulates D2 deiodinase which controls T4 -> T3 conversion. As overall output from the thyroid begins to decline, the pituitary can compensate by increasing TSH production to not only direct increased thyroid hormone output, but also to maintain circulating T3 by increasing D2 activity, and thus peripheral T4 -> T3 conversion. This situation may manifest as moderate-high fT3, but a barely in-range fT4 and total T4, with a slightly elevated TSH between 2.5 - 4. However, although circulating T3 levels are maintained, there are various cells which rely solely on the uptake of T4 for local conversion to T3 rather than the direct uptake of T3 itself, which is why maintaining an optimal total and fT4 is extremely important, despite T4 itself being a largely inactive hormone — this is especially true for cells in the CNS, as T4 crosses the blood-brain-barrier more readily than T3; google 'hyperthyroid dementia' which can result from high-dose T3 monotherapy suppressing systemic T4 levels for more information. My own thyroid panel has always fit the above, and my body temps, heart rate and other hypothyroid symptoms respond strongly to taking thyroid hormone, despite all my labs being within range, and fT3 being 'optimal'. Unfortunately, I struggle to tolerate thyroid hormone long-term as it causes my cortisol to drop below range which produces extremely severe symptoms, and subsequently the forced cessation of treatment. Low cortisol is often associated with hypothryoidism as the adrenals themselves require adequate thyroid hormone for cholesterol -> pregnenolone conversion, and thus the production of their own hormones. I'm hoping some combination of thyroid + hydrocortisone and/or pregnenolone and/or progesterone will allow me to make progress in addressing my hypothyroid symptoms, but there is still a lot of experimentation needed. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
FT4 levels on tests and brain fog
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