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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
FT using TruT vs Dialysis methods
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<blockquote data-quote="madman" data-source="post: 163652" data-attributes="member: 13851"><p><a href="https://academic.oup.com/edrv/article/38/4/302/3897170" target="_blank">Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications</a></p><p></p><p></p><p></p><p></p><p><strong>A recent reappraisal of testosterone binding to SHBG using modern biophysical techniques indicated that <span style="color: rgb(184, 49, 47)">the two binding sites on the SHBG dimer are not equivalent </span>and that there is an allosteric interaction between the binding sites on the SHBG dimer such that <span style="color: rgb(184, 49, 47)">the second testosterone molecule binds SHBG with a </span><span style="color: rgb(44, 130, 201)">substantially different affinity</span><span style="color: rgb(184, 49, 47)"> than the first binding site </span>(34). </strong></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(44, 130, 201)">*SUBSTANTIALLY DIFFERENT AFFINITY</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 163652, member: 13851"] [URL='https://academic.oup.com/edrv/article/38/4/302/3897170']Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications[/URL] [B]A recent reappraisal of testosterone binding to SHBG using modern biophysical techniques indicated that [COLOR=rgb(184, 49, 47)]the two binding sites on the SHBG dimer are not equivalent [/COLOR]and that there is an allosteric interaction between the binding sites on the SHBG dimer such that [COLOR=rgb(184, 49, 47)]the second testosterone molecule binds SHBG with a [/COLOR][COLOR=rgb(44, 130, 201)]substantially different affinity[/COLOR][COLOR=rgb(184, 49, 47)] than the first binding site [/COLOR](34). [/B] [B][COLOR=rgb(44, 130, 201)]*SUBSTANTIALLY DIFFERENT AFFINITY[/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
FT using TruT vs Dialysis methods
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