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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Free Testosterone & cardiometabolic parameters in men - comparison of algorithms
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<blockquote data-quote="madman" data-source="post: 195423" data-attributes="member: 13851"><p><strong><em>- in phase I studies, we demonstrated that TruTTM algorithm provides accurate free T values that match those obtained using the equilibrium dialysis in healthy and hypogonadal men</em></strong></p><p></p><p><em><strong>- we have also shown that the binding parameters that have formed the basis of previous equations (e.g., Vermeulen) are incorrect and that free T values derived using these equations deviate substantially from free T measured by equilibrium dialysis</strong></em></p><p><em><strong></strong></em></p><p><em><strong>- the phase I studies have led to the adoption of the TruTTM algorithm at several institutions</strong></em></p><p><em><strong></strong></em></p><p><em><strong>- the phase II program will continue the development of the TruTTM algorithm by validating it in common conditions characterized by altered SHBG concentration, such as obesity and aging (AIM 1), in healthy women across the menstrual cycle, and in women with PCOS (AIM 2)</strong></em></p><p><em><strong></strong></em></p><p><em><strong>- <u>we will generate population-based reference ranges for free T</u> (AIM 3)</strong></em></p><p><em><strong></strong></em></p><p><em><strong>- <u>phase II also includes plans for commercialization of the TruTTM algorithm using a HIPAA compliant infrastructure for its clinical adoption</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>-<u>the phase II program will provide validation of TruTTM algorithm in the two most common clinical indications for free T measurement</u>? men suspected of hypogonadism and altered SHBG levels, and women with hyperandrogenic disorders</strong></em></p><p><em><strong></strong></em></p><p><em><strong>- <u>it will also enable the development of a HIPAA compliant platform that can be embedded into the electronic medical record for wider clinical adoption and for improving clinical care</u></strong></em></p><p></p><p></p><p></p><p>Project Start 2014-09-15</p><p><strong>Project End </strong>2019-05-31<strong> (2021-05-31)</strong></p><p></p><p></p><p></p><p><a href="http://grantome.com/grant/NIH/R44-AG045011-02" target="_blank">Phase II: Research and Commercialization of TruT Algorithm for Free Testosterone</a></p></blockquote><p></p>
[QUOTE="madman, post: 195423, member: 13851"] [B][I]- in phase I studies, we demonstrated that TruTTM algorithm provides accurate free T values that match those obtained using the equilibrium dialysis in healthy and hypogonadal men[/I][/B] [I][B]- we have also shown that the binding parameters that have formed the basis of previous equations (e.g., Vermeulen) are incorrect and that free T values derived using these equations deviate substantially from free T measured by equilibrium dialysis - the phase I studies have led to the adoption of the TruTTM algorithm at several institutions - the phase II program will continue the development of the TruTTM algorithm by validating it in common conditions characterized by altered SHBG concentration, such as obesity and aging (AIM 1), in healthy women across the menstrual cycle, and in women with PCOS (AIM 2) - [U]we will generate population-based reference ranges for free T[/U] (AIM 3) - [U]phase II also includes plans for commercialization of the TruTTM algorithm using a HIPAA compliant infrastructure for its clinical adoption[/U] -[U]the phase II program will provide validation of TruTTM algorithm in the two most common clinical indications for free T measurement[/U]? men suspected of hypogonadism and altered SHBG levels, and women with hyperandrogenic disorders - [U]it will also enable the development of a HIPAA compliant platform that can be embedded into the electronic medical record for wider clinical adoption and for improving clinical care[/U][/B][/I] Project Start 2014-09-15 [B]Project End [/B]2019-05-31[B] (2021-05-31)[/B] [URL='http://grantome.com/grant/NIH/R44-AG045011-02']Phase II: Research and Commercialization of TruT Algorithm for Free Testosterone[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Free Testosterone & cardiometabolic parameters in men - comparison of algorithms
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