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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
For those who are struggling on TRT
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<blockquote data-quote="Cataceous" data-source="post: 228496" data-attributes="member: 38109"><p>I'd bet against this. And it's easy to get off-track by over-fixating on total testosterone. The range gets skewed by the variance in SHBG. You can't use plus-side outliers who likely have high SHBG to justify similar total testosterone levels in men with normal SHBG. Here's a <a href="https://pubmed.ncbi.nlm.nih.gov/17036414/" target="_blank">different study</a> with data collected in roughly the same time period. Mean total testosterone is 582 ng/dL, SD 159 ng/dL. An outlier at two standard deviations has a total testosterone of 900 ng/dL. Meanwhile, Vermeulen calculated free testosterone averages 12.7 ng/dL, SD 3.66 ng/dL. Someone with that average free testosterone can achieve a total testosterone of 900 ng/dL by having an SHBG of 66 nMol/L—and there are a few in the study with SHBG around that. Looking at it another way, if we take someone with the average SHBG for the study—30.3 nMol/L—and make him have a total testosterone of 900 ng/dL then his free testosterone is more than two standard deviations above the mean and probably inappropriate for him.</p><p></p><p>We mention this frequently, and the correct figure for cypionate is 70% testosterone by weight.</p><p></p><p>Every study I've seen concludes that absorption is close to 100%. Do you have evidence to the contrary?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 228496, member: 38109"] I'd bet against this. And it's easy to get off-track by over-fixating on total testosterone. The range gets skewed by the variance in SHBG. You can't use plus-side outliers who likely have high SHBG to justify similar total testosterone levels in men with normal SHBG. Here's a [URL='https://pubmed.ncbi.nlm.nih.gov/17036414/']different study[/URL] with data collected in roughly the same time period. Mean total testosterone is 582 ng/dL, SD 159 ng/dL. An outlier at two standard deviations has a total testosterone of 900 ng/dL. Meanwhile, Vermeulen calculated free testosterone averages 12.7 ng/dL, SD 3.66 ng/dL. Someone with that average free testosterone can achieve a total testosterone of 900 ng/dL by having an SHBG of 66 nMol/L—and there are a few in the study with SHBG around that. Looking at it another way, if we take someone with the average SHBG for the study—30.3 nMol/L—and make him have a total testosterone of 900 ng/dL then his free testosterone is more than two standard deviations above the mean and probably inappropriate for him. We mention this frequently, and the correct figure for cypionate is 70% testosterone by weight. Every study I've seen concludes that absorption is close to 100%. Do you have evidence to the contrary? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
For those who are struggling on TRT
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