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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
For those who are struggling on TRT
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<blockquote data-quote="Fortunate" data-source="post: 227930" data-attributes="member: 42264"><p>One of the most compelling facts about the success story is that [USER=17540]@sh1973[/USER] feels even and stable throughout the week. This would suggest that he is at a steady state, with predictable and regular peaks and valleys.</p><p></p><p>I recall reading in the Xyosted study, <u>Pharmacokinetic Profile of Subcutaneous Testosterone Enanthate Delivered via a Novel, Prefilled Single-Use Autoinjector: A Phase II Study</u>, that with the 50mg weekly injection, there was no dose accumulation. The guys at this dose were hitting their trough every week and starting from the same bottom by the time of their next injection every week. </p><p></p><p>There were only 14 subjects in the 50mg treatment arm, so not a huge number. That said, I wonder how this fits with [USER=17540]@sh1973[/USER]'s experience? Do we think he is rising from trough to peak every week, like in the Xyosted study? If so, how does he feel good later in the week? His Cavg would obviously be higher than with no treatment at all, but if the data is correct, he should be hitting a bottom late in the week. </p><p></p><p>Is the data not accurate? Is he an outlier? Or, is this just one of those weird physiology/adaptation things we can't explain?</p></blockquote><p></p>
[QUOTE="Fortunate, post: 227930, member: 42264"] One of the most compelling facts about the success story is that [USER=17540]@sh1973[/USER] feels even and stable throughout the week. This would suggest that he is at a steady state, with predictable and regular peaks and valleys. I recall reading in the Xyosted study, [U]Pharmacokinetic Profile of Subcutaneous Testosterone Enanthate Delivered via a Novel, Prefilled Single-Use Autoinjector: A Phase II Study[/U], that with the 50mg weekly injection, there was no dose accumulation. The guys at this dose were hitting their trough every week and starting from the same bottom by the time of their next injection every week. There were only 14 subjects in the 50mg treatment arm, so not a huge number. That said, I wonder how this fits with [USER=17540]@sh1973[/USER]'s experience? Do we think he is rising from trough to peak every week, like in the Xyosted study? If so, how does he feel good later in the week? His Cavg would obviously be higher than with no treatment at all, but if the data is correct, he should be hitting a bottom late in the week. Is the data not accurate? Is he an outlier? Or, is this just one of those weird physiology/adaptation things we can't explain? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
For those who are struggling on TRT
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