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New evidence suggests that fluoride may be an sexual hormone disruptor. From the abstract:

We conducted a cross-sectional study in rural areas of Henan province in  China to explore the interaction between the estrogen receptor alpha  (ER&#945 gene and fluoride exposure on reproductive hormone levels in male  farmers living in the endemic fluorosis villages. The results showed  that fluoride exposure significantly increased the serum level of  estradiol in the hypothalamic-pituitary-testicular (HPT) axis in male  farmers. Moreover, the observations indicated that fluoride exposure and  genetic markers had an interaction on serum concentration of  follicle-stimulating hormone and estradiol, and the interaction among  different loci of the ERα gene could impact the serum testosterone  level. Findings in the present work suggest that chronic fluoride  exposure in drinking water could modulate the levels of reproductive  hormones in males living in endemic fluorosis areas, and the interaction  between fluoride exposure and ERα polymorphisms might affect the serum  levels of hormones in the HPT axis in male farmers.