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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
First lab post! Posted an intro as well. Pre-TRT. High DHEA and IGF-1.
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<blockquote data-quote="Cataceous" data-source="post: 216430" data-attributes="member: 38109"><p>It's very common for TRT to drive LH, FSH and GnRH to quite low levels. I'm less certain about the overall effect on kisspeptin because of other production sites. Nonetheless, it seems reasonable to hypothesize that levels are reduced. With many of these hormones there are receptors around the body whose functions are not yet understood. We don't know what we're doing by depriving them of their ligands. There are broader indirect effects. I recall one of the bigger names in the field mentioning something like 20-30 hormones influenced by TRT. Even at seemingly normal doses it's easy to drive up testosterone higher than is normal for your physiology. Then you might see lowered HDL, elevated hematocrit, high estradiol, along with more subtle problems.</p><p></p><p>Enclomiphene is different in that it stimulates the HPTA. It blocks the negative feedback of estradiol at both the hypothalamus and pituitary, leading to greater production of kisspeptin, GnRH, LH, FSH and testosterone. This is good, but you want to adjust the dose so that you're not making too much of anything either. It's possible to end up with too much testosterone and create some of the side effects seen with TRT. </p><p></p><p>Testosterone nasal gel has a very short half-life, less than an hour. This means a fairly quick return to lower baseline testosterone levels, which is what allows the HPTA to continue to function. With three doses a day there is some reduction in HPTA activity, but it's small compared to the complete shutdown seen with regular TRT. The success of the clinical trials for Natesto suggests that the peak testosterone levels have some independent importance in the benefits we get from testosterone. Meshing with this is the fact that diurnal variation in serum testosterone in healthy young men can see their levels fall from a normal morning peak to seemingly hypogonadal levels later in the day. There may be some advantage in this intra-day variability. We also know that it attenuates with age.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 216430, member: 38109"] It's very common for TRT to drive LH, FSH and GnRH to quite low levels. I'm less certain about the overall effect on kisspeptin because of other production sites. Nonetheless, it seems reasonable to hypothesize that levels are reduced. With many of these hormones there are receptors around the body whose functions are not yet understood. We don't know what we're doing by depriving them of their ligands. There are broader indirect effects. I recall one of the bigger names in the field mentioning something like 20-30 hormones influenced by TRT. Even at seemingly normal doses it's easy to drive up testosterone higher than is normal for your physiology. Then you might see lowered HDL, elevated hematocrit, high estradiol, along with more subtle problems. Enclomiphene is different in that it stimulates the HPTA. It blocks the negative feedback of estradiol at both the hypothalamus and pituitary, leading to greater production of kisspeptin, GnRH, LH, FSH and testosterone. This is good, but you want to adjust the dose so that you're not making too much of anything either. It's possible to end up with too much testosterone and create some of the side effects seen with TRT. Testosterone nasal gel has a very short half-life, less than an hour. This means a fairly quick return to lower baseline testosterone levels, which is what allows the HPTA to continue to function. With three doses a day there is some reduction in HPTA activity, but it's small compared to the complete shutdown seen with regular TRT. The success of the clinical trials for Natesto suggests that the peak testosterone levels have some independent importance in the benefits we get from testosterone. Meshing with this is the fact that diurnal variation in serum testosterone in healthy young men can see their levels fall from a normal morning peak to seemingly hypogonadal levels later in the day. There may be some advantage in this intra-day variability. We also know that it attenuates with age. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
First lab post! Posted an intro as well. Pre-TRT. High DHEA and IGF-1.
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