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Every doctor that I have dealt with/heard of who has happy and satisfied patients initiates therapy in a split-dosing protocol in which the total weekly dose does not exceed 150mg (unless there is an eye-poppingly high SHBG value in play). Is that a small sample size? It certainly is. Perhaps 18 doctors in Canada and the US, and one in the UK.However, it's a matter of half-life, estradiol, and SHBG. Weighing those factors, there is a consensus that moderation, particularly at the start of therapy lends itself to greater success in the long run. It's "easier for the patient to climb higher rather than stumble down" (my own doctor's phrase).
Every doctor that I have dealt with/heard of who has happy and satisfied patients initiates therapy in a split-dosing protocol in which the total weekly dose does not exceed 150mg (unless there is an eye-poppingly high SHBG value in play). Is that a small sample size? It certainly is. Perhaps 18 doctors in Canada and the US, and one in the UK.
However, it's a matter of half-life, estradiol, and SHBG. Weighing those factors, there is a consensus that moderation, particularly at the start of therapy lends itself to greater success in the long run. It's "easier for the patient to climb higher rather than stumble down" (my own doctor's phrase).
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