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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Finasteride (Proscar, Propecia) Use Associated with ED, Low Testosterone
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<blockquote data-quote="Nelson Vergel" data-source="post: 50652" data-attributes="member: 3"><p><strong>Persistent Sexual Dysfunction with Finasteride 1mg Taken for Hair Loss.</strong></p><p>Guo M, et al. Pharmacotherapy. 2016.</p><p></p><p>Abstract</p><p>PURPOSE: To examine the risk of persistent sexual dysfunction (PSD) with finasteride 1mg.</p><p></p><p>METHODS: We conducted a retrospective cohort study using the IMS U.S. health claims database. From an original cohort of 6,110,723 patients, we identified 1390 men who had stopped using finasteride 1mg and 20,000 randomly selected age- and calendar time-matched users of omeprazole from 2006 to 2014. First PSD event was defined as 1) the first PSD diagnosis through the first International Classification for Diseases, Ninth Revision Clinical Modification [ICD-9-CM]) code for sexual dysfunction and 2) use of a phosphodiesterase inhibitor (sildenafil, tadalafil, or vardenafil) RESULTS: In the primary analysis, we identified 1,390 men taking finasteride 1mg and 20,000 omeprazole users. The median time to first PSD event after discontinuation ofa finasteride 1mg prescription was 339 days (SD, 334 days). The rate of PSD for finasteride 1mg users and omeprazole users was 37.9 and 15 per 1000-person-years, respectively. For the primary analysis of sexual dysfunction, the adjusted hazard ratio (HR) comparing finasteride 1mg users to omeprazole users was 1.62 (1.14-2.29). Adjusted HR in the secondary analysis comparing finasteride users to omeprazole users with respect to the first phosphodiesterase inhibitor was 2.73 (2.01-3.69).</p><p></p><p>CONCLUSIONS: The risk of PSD in men who stopped finasteride 1mg therapy was higher than for omeprazole users. Patients who stopped finasteride therapy sought physician visits for sexual dysfunction up to 1 year after stopping finasteride. This article is protected by copyright. All rights reserved.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 50652, member: 3"] [B]Persistent Sexual Dysfunction with Finasteride 1mg Taken for Hair Loss.[/B] Guo M, et al. Pharmacotherapy. 2016. Abstract PURPOSE: To examine the risk of persistent sexual dysfunction (PSD) with finasteride 1mg. METHODS: We conducted a retrospective cohort study using the IMS U.S. health claims database. From an original cohort of 6,110,723 patients, we identified 1390 men who had stopped using finasteride 1mg and 20,000 randomly selected age- and calendar time-matched users of omeprazole from 2006 to 2014. First PSD event was defined as 1) the first PSD diagnosis through the first International Classification for Diseases, Ninth Revision Clinical Modification [ICD-9-CM]) code for sexual dysfunction and 2) use of a phosphodiesterase inhibitor (sildenafil, tadalafil, or vardenafil) RESULTS: In the primary analysis, we identified 1,390 men taking finasteride 1mg and 20,000 omeprazole users. The median time to first PSD event after discontinuation ofa finasteride 1mg prescription was 339 days (SD, 334 days). The rate of PSD for finasteride 1mg users and omeprazole users was 37.9 and 15 per 1000-person-years, respectively. For the primary analysis of sexual dysfunction, the adjusted hazard ratio (HR) comparing finasteride 1mg users to omeprazole users was 1.62 (1.14-2.29). Adjusted HR in the secondary analysis comparing finasteride users to omeprazole users with respect to the first phosphodiesterase inhibitor was 2.73 (2.01-3.69). CONCLUSIONS: The risk of PSD in men who stopped finasteride 1mg therapy was higher than for omeprazole users. Patients who stopped finasteride therapy sought physician visits for sexual dysfunction up to 1 year after stopping finasteride. This article is protected by copyright. All rights reserved. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Finasteride (Proscar, Propecia) Use Associated with ED, Low Testosterone
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