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ExcelFemale
HRT in Women
Finasteride (Propecia) for Scalp Hair Loss and Excess Facial Hair in Women: Safe and Effective?
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<blockquote data-quote="madman" data-source="post: 192766" data-attributes="member: 13851"><p><strong>*Finasteride is a competitive inhibitor of 5-alpha-reductase, an enzyme that catalyzes the conversion of testosterone to dihydrotestosterone (DHT). <u>While there are multiple 5-alpha-reductase isotypes in the body, finasteride specifically acts on isoenzyme II, which is found in the uterus, endometrium, fallopian tube, prostate, male genitalia, hair follicle root sheath, and liver</u>.1–8</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>*Dutasteride is another competitive inhibitor of 5-alpha-reductase, <u>three times as potent as finasteride at inhibiting type II, and more than 100 times as effective at inhibiting type I</u>.17 </strong></p><p><strong></strong></p><p><strong>*<u>Concerns regarding the adverse effects of finasteride and dutasteride used in men has led the NIH to add the controversial “post-finasteride syndrome”, described as a persistent sexual, neurological, and physical adverse reaction, to its Genetic and Rare Diseases Information website</u>.16,18</strong></p></blockquote><p></p>
[QUOTE="madman, post: 192766, member: 13851"] [B]*Finasteride is a competitive inhibitor of 5-alpha-reductase, an enzyme that catalyzes the conversion of testosterone to dihydrotestosterone (DHT). [U]While there are multiple 5-alpha-reductase isotypes in the body, finasteride specifically acts on isoenzyme II, which is found in the uterus, endometrium, fallopian tube, prostate, male genitalia, hair follicle root sheath, and liver[/U].1–8 *Dutasteride is another competitive inhibitor of 5-alpha-reductase, [U]three times as potent as finasteride at inhibiting type II, and more than 100 times as effective at inhibiting type I[/U].17 *[U]Concerns regarding the adverse effects of finasteride and dutasteride used in men has led the NIH to add the controversial “post-finasteride syndrome”, described as a persistent sexual, neurological, and physical adverse reaction, to its Genetic and Rare Diseases Information website[/U].16,18[/B] [/QUOTE]
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ExcelFemale
HRT in Women
Finasteride (Propecia) for Scalp Hair Loss and Excess Facial Hair in Women: Safe and Effective?
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