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<blockquote data-quote="madman" data-source="post: 205783" data-attributes="member: 13851"><p><strong><em>He's suggested started with 80mg Test Enanthate injected subQ weekly and work from there. No AI until we see labs or if I start showing signs of high E2. He also recommended holding off on HCG since I have no plans for more children but is willing to add it at any time if we feel necessary. Dosage seems a little low, but I'm willing to start small and work up from there.</em></strong></p><p></p><p>Welcome!</p><p></p><p>The best piece of advice is to start low and go slow.</p><p></p><p>100 mg/week would be a good starting point especially when jumping on once-weekly injections.</p><p></p><p>Smart move starting on a T only protocol let alone avoiding the use of an AI as we want to see how your body reacts to testosterone and where said protocol (dose T/injection frequency) has your TT, FT, estradiol, DHT levels let alone other blood health markers such as CBC which includes RBCs/hemoglobin/hematocrit.</p><p></p><p>Keep in mind that testosterone metabolites<strong> <u><em>estradiol</em></u> and</strong> <strong>DHT</strong> are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects.</p><p></p><p>Having healthy estradiol levels is needed as it will have a positive impact on mood, energy, libido, erectile function, cardiovascular/brain/bone/immune system health, body composition.</p><p></p><p>Even if your estradiol ends up being high which is a given if you drive up your T levels you may very well feel great.</p><p></p><p>Some men do need to use an AI (micro-doses) to control e2 but it comes down to the individual and is not a given.</p><p></p><p>The addition of hCG can be added eventually if you want to prevent/minimize testicular atrophy let alone maintain fertility while using exogenous T.</p><p></p><p></p><p></p><p></p><p><strong><em>My one question around this is whether I'd be better going to every 3.5 days but will probably see how weekly works first. Doc didn't feel it was necessary since I was doing subQ.</em></strong></p><p></p><p>Although some men will do well injecting once weekly many men on trt tend to inject more frequently as in twice weekly (every 3.5 days), M/W/F/, EOD, or even daily.</p><p></p><p>Keep in mind that when injecting once weekly that there will be a significant difference in peak--->trough especially when injecting strictly IM let alone blood levels will not be as stable throughout the week which can result in having a negative impact on one's mood, energy, libido, erectile function, recovery throughout the week.</p><p></p><p>If you plan on once-weekly injections strictly sub-q than peak--->trough may not be as extreme let alone blood levels may be more stable throughout the week.</p><p></p><p>Even then I would be more concerned with where your SHBG sits as not only will it have a significant impact on free testosterone but can also dictate what injection frequency may suit you best.</p><p></p><p>If your SHBG is high/highish then you may fair well using once-weekly injections especially if you inject strictly sub-q.</p><p></p><p>In cases of low/lowish SHBG, a more frequent injection protocol (EOD/daily) may be needed.</p><p></p><p>Comes down to the individual and what works best.</p><p></p><p></p><p></p><p><strong><u>once-weekly injections (IM)</u></strong></p><p><strong></strong></p><p><strong>[URL unfurl="true"]https://www.excelmale.com/forum/threads/variance-in-peak-and-trough-testosterone-levels-in-men-using-intramuscular-testosterone.15977/[/URL]</strong></p><p><strong></strong></p><p><strong>CONCLUSIONS:</strong> In our population of patients on<strong> <u><em>stable IM T dose, there was a wide mean variation in both Tp (23%) and Tt (17.5%)</em></u><em>. </em></strong><em><strong><u>In addition to that, 25% of patients had a maximum Tp change greater than 50% and a maximum Tt change greater than 35%</u></strong></em><strong>. </strong>Clinicians should be aware of this high variability in levels when deciding on dose adjustment.</p><p></p><p></p><p></p><p></p><p><strong><u>once-weekly injections (sub-q)</u></strong></p><p><strong></strong></p><p><strong>Pharmacokinetic Profile of Subcutaneous Testosterone Enanthate Delivered via a Novel, Prefilled Single-Use Autoinjector: A Phase II Study (2015)</strong></p><p>[ATTACH=full]15828[/ATTACH]</p><p>[ATTACH=full]15829[/ATTACH]</p><p><strong>Figure 3 Mean total testosterone concentration vs. time. Mean total testosterone (TT) concentration across weeks 1, 5, and 6 for subcutaneous (SC) testosterone enanthate (TE) treatment arms. (A) <u>50 mg SC TE</u> (open shapes). (B) <u>100 mg SC TE</u> (closed shapes). SD = standard deviation</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Safety of a New Subcutaneous Testosterone Enanthate Auto-Injector: Results of a 26-Week Study (2019)</strong></p><p></p><p>[ATTACH=full]15830[/ATTACH]</p><p><strong>Figure 3. <u>Panel A</u> is the weekly pharmacokinetic profile of TT concentrations at weeks 1, 6, and 12 for patients in the PK substudy.</strong></p></blockquote><p></p>
[QUOTE="madman, post: 205783, member: 13851"] [B][I]He's suggested started with 80mg Test Enanthate injected subQ weekly and work from there. No AI until we see labs or if I start showing signs of high E2. He also recommended holding off on HCG since I have no plans for more children but is willing to add it at any time if we feel necessary. Dosage seems a little low, but I'm willing to start small and work up from there.[/I][/B] Welcome! The best piece of advice is to start low and go slow. 100 mg/week would be a good starting point especially when jumping on once-weekly injections. Smart move starting on a T only protocol let alone avoiding the use of an AI as we want to see how your body reacts to testosterone and where said protocol (dose T/injection frequency) has your TT, FT, estradiol, DHT levels let alone other blood health markers such as CBC which includes RBCs/hemoglobin/hematocrit. Keep in mind that testosterone metabolites[B] [U][I]estradiol[/I][/U] and[/B] [B]DHT[/B] are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects. Having healthy estradiol levels is needed as it will have a positive impact on mood, energy, libido, erectile function, cardiovascular/brain/bone/immune system health, body composition. Even if your estradiol ends up being high which is a given if you drive up your T levels you may very well feel great. Some men do need to use an AI (micro-doses) to control e2 but it comes down to the individual and is not a given. The addition of hCG can be added eventually if you want to prevent/minimize testicular atrophy let alone maintain fertility while using exogenous T. [B][I]My one question around this is whether I'd be better going to every 3.5 days but will probably see how weekly works first. Doc didn't feel it was necessary since I was doing subQ.[/I][/B] Although some men will do well injecting once weekly many men on trt tend to inject more frequently as in twice weekly (every 3.5 days), M/W/F/, EOD, or even daily. Keep in mind that when injecting once weekly that there will be a significant difference in peak--->trough especially when injecting strictly IM let alone blood levels will not be as stable throughout the week which can result in having a negative impact on one's mood, energy, libido, erectile function, recovery throughout the week. If you plan on once-weekly injections strictly sub-q than peak--->trough may not be as extreme let alone blood levels may be more stable throughout the week. Even then I would be more concerned with where your SHBG sits as not only will it have a significant impact on free testosterone but can also dictate what injection frequency may suit you best. If your SHBG is high/highish then you may fair well using once-weekly injections especially if you inject strictly sub-q. In cases of low/lowish SHBG, a more frequent injection protocol (EOD/daily) may be needed. Comes down to the individual and what works best. [B][U]once-weekly injections (IM)[/U] [URL unfurl="true"]https://www.excelmale.com/forum/threads/variance-in-peak-and-trough-testosterone-levels-in-men-using-intramuscular-testosterone.15977/[/URL] CONCLUSIONS:[/B] In our population of patients on[B] [U][I]stable IM T dose, there was a wide mean variation in both Tp (23%) and Tt (17.5%)[/I][/U][I]. [/I][/B][I][B][U]In addition to that, 25% of patients had a maximum Tp change greater than 50% and a maximum Tt change greater than 35%[/U][/B][/I][B]. [/B]Clinicians should be aware of this high variability in levels when deciding on dose adjustment. [B][U]once-weekly injections (sub-q)[/U] Pharmacokinetic Profile of Subcutaneous Testosterone Enanthate Delivered via a Novel, Prefilled Single-Use Autoinjector: A Phase II Study (2015)[/B] [ATTACH type="full" alt="Screenshot (6443).png"]15828[/ATTACH] [ATTACH type="full" alt="Screenshot (6444).png"]15829[/ATTACH] [B]Figure 3 Mean total testosterone concentration vs. time. Mean total testosterone (TT) concentration across weeks 1, 5, and 6 for subcutaneous (SC) testosterone enanthate (TE) treatment arms. (A) [U]50 mg SC TE[/U] (open shapes). (B) [U]100 mg SC TE[/U] (closed shapes). SD = standard deviation Safety of a New Subcutaneous Testosterone Enanthate Auto-Injector: Results of a 26-Week Study (2019)[/B] [ATTACH type="full" alt="Screenshot (6445).png"]15830[/ATTACH] [B]Figure 3. [U]Panel A[/U] is the weekly pharmacokinetic profile of TT concentrations at weeks 1, 6, and 12 for patients in the PK substudy.[/B] [/QUOTE]
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