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<blockquote data-quote="madman" data-source="post: 116662" data-attributes="member: 13851"><p>As others have stated your SHBG should have been tested pre-trt as ones SHBG will dictate dose/injection frequency and is critical to the effectiveness of trt.</p><p></p><p>Knowing SHBG before starting trt can save many grief as it takes 6 weeks for testosterone levels to stabilize. Now you found out 6 weeks after starting your protocol that your SHBG is low hence why your protocol is not optimal.</p><p></p><p>Do understand that just because 100mg/week of testosterone bumped your TT level up 300 ng/dL in no way does it mean that adding another 100mg/week is going to cause the same increase.....200mg/week is a rather large dose of testosterone for trt and that is a significant increase from injecting 100mg/week.</p><p></p><p>Ones SHBG, sensitivity of the AR (androgen receptor) play a big role in what dose of testosterone is needed and how one responds.</p><p></p><p>Seeing as your SHBG looks to be low 22 nmol/L (you did not provide range) you would do better injecting lower doses of testosterone daily or EOD and if anything even though TT is good to know and your numbers may not seem impressive on paper FT is what really matters as it is the unbound active fraction of testosterone.</p><p></p><p>Men with low/lowish SHBG can usually obtain higher FT using lower doses of testosterone injected more frequently.</p><p></p><p>As you know your e2 test was done using the wrong method and the sensitive assay (LC/MS-MS) is needed to truly know where your e2 sits.</p><p></p><p>You state " I am injecting 100mg per week and that got me up about 300 points so i was thinking to take it up to 200 per week 100 per injection to keep E2 down and to keep it more stable. do you think this would be the right choice or would it be to much? </p><p></p><p>.....so you have no idea where your e2 sits as it was not tested with the sensitive estradiol assay and now you want to double your dose from 100mg/week--->200mg/week (100mg every 3.5 days), thinking it will keep e2 down and more stable when in fact it will skyrocket especially seeing as you have low SHBG.</p><p></p><p>I would definitely look into injecting EOD or daily using lower doses of testosterone and definitely not 200mg/week.</p><p></p><p>You need to provide ranges for TT, FT, SHBG, E2?</p></blockquote><p></p>
[QUOTE="madman, post: 116662, member: 13851"] As others have stated your SHBG should have been tested pre-trt as ones SHBG will dictate dose/injection frequency and is critical to the effectiveness of trt. Knowing SHBG before starting trt can save many grief as it takes 6 weeks for testosterone levels to stabilize. Now you found out 6 weeks after starting your protocol that your SHBG is low hence why your protocol is not optimal. Do understand that just because 100mg/week of testosterone bumped your TT level up 300 ng/dL in no way does it mean that adding another 100mg/week is going to cause the same increase.....200mg/week is a rather large dose of testosterone for trt and that is a significant increase from injecting 100mg/week. Ones SHBG, sensitivity of the AR (androgen receptor) play a big role in what dose of testosterone is needed and how one responds. Seeing as your SHBG looks to be low 22 nmol/L (you did not provide range) you would do better injecting lower doses of testosterone daily or EOD and if anything even though TT is good to know and your numbers may not seem impressive on paper FT is what really matters as it is the unbound active fraction of testosterone. Men with low/lowish SHBG can usually obtain higher FT using lower doses of testosterone injected more frequently. As you know your e2 test was done using the wrong method and the sensitive assay (LC/MS-MS) is needed to truly know where your e2 sits. You state " I am injecting 100mg per week and that got me up about 300 points so i was thinking to take it up to 200 per week 100 per injection to keep E2 down and to keep it more stable. do you think this would be the right choice or would it be to much? .....so you have no idea where your e2 sits as it was not tested with the sensitive estradiol assay and now you want to double your dose from 100mg/week--->200mg/week (100mg every 3.5 days), thinking it will keep e2 down and more stable when in fact it will skyrocket especially seeing as you have low SHBG. I would definitely look into injecting EOD or daily using lower doses of testosterone and definitely not 200mg/week. You need to provide ranges for TT, FT, SHBG, E2? [/QUOTE]
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