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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Finally Got my Full Panel...Way Low Testosterone
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<blockquote data-quote="John O'Connor" data-source="post: 37658" data-attributes="member: 13064"><p>Chris - Only 50mcg??? Are you confusing the typical Synthroid/levothyroxine dose based in mcg (micrograms) with that of a typical NDT (dessicated thyroid), which is measured in mg (milligrams)?</p><p>I don't have a great source for this, but this is the conversion I found online:</p><p>1 grain (60 mg) of Armour thyroid contains 9 mcg of T3 and 38 mcg of T4. </p><p></p><p>I just want to clarify - 50mcg is a common dose for Synthroid (generic = Levothyroxine) for individuals with moderately elevated TSH in the 3.0-5.0 range. Many individuals take just 25mcg or 37.5mcg.</p><p></p><p>I was originally diagnosed with Hashimoto's thyroiditis with TSH of 3.8, and Anti-TPO of 800 (0-50). I was put on 50mcg, and it lowered my TSH to a range of 0.80 -1.20 consistently.</p><p></p><p>After 1 year on levothyroxine my TSH jumped to the 1.5-1.8 range, and my dose was increased to 75mcg. After a couple months at this higher dose my TSH dropped too low (to 0.60) and my doctor immediately switched me back to the 50mcg dose.</p><p></p><p>These changes were a learning experience. When I initially began taking levothyroxine (2006) I took it 1st thing in the morning on an empty stomach and did not eat for 1 full hour after taking it.</p><p>As time went on, I stopped fasting for the full hour. Some days i waited 45 minutes to eat while other days I might only wait 30 minutes. This caused me to need the higher 75mcg dose, as eating sooner was impairing the absorption rate of the medication. But when I began taking it regulary with a full 1 hour before food - the 75mcg dose was too much - thus the low 0.60 TSH measurement.</p><p></p><p>Note I'm 6-0 tall, and weigh 180. So a lower dose works well for me as someone with only mild thyroid function impairment (TSH 3.8 without meds).</p><p></p><p>Someone like NSM, who is 6-0, but weighs 300 lbs, may need an equal or higher dose to produce a similar effect, despite having a less significant impairment of thyroid function (TSH 2.7). </p><p></p><p>Here is a link to a study showing correlation between dosage and body mass index. Note these patients had their entire thyroid removed due to thyroid cancer (total thyroidectomy) - so they have 100% impairment, as opposed to NSM and myself who only have mild impairment of our thyroid function. So it is logical that they would need much higher doses, likely 2x to 3x higher than our 50mcg doses.</p><p></p><p><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658157/" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658157/</a></p><p>"The conventional method of thyroid replacement therapy involved an empiric dose of 100-150 micrograms per day. Following this regimen, between 21-37% of patients attained a euthyroid state at initial follow up."</p><p></p><p>Euthyroid definition = the state of having normal thyroid function (or normal Thyroid hormone levels as a result of thyroid hormone replacement via medication (synthroid, levothyroxine, etc.)</p><p></p><p>Note - we are all learning here - and I do not have all the answers, I was just concerned that some people reading Chris's comment "Wow, its only 50mcg" might interpret that incorrectly.</p><p></p><p>Please correct me if I misunderstood anything. All the best, John</p></blockquote><p></p>
[QUOTE="John O'Connor, post: 37658, member: 13064"] Chris - Only 50mcg??? Are you confusing the typical Synthroid/levothyroxine dose based in mcg (micrograms) with that of a typical NDT (dessicated thyroid), which is measured in mg (milligrams)? I don't have a great source for this, but this is the conversion I found online: 1 grain (60 mg) of Armour thyroid contains 9 mcg of T3 and 38 mcg of T4. I just want to clarify - 50mcg is a common dose for Synthroid (generic = Levothyroxine) for individuals with moderately elevated TSH in the 3.0-5.0 range. Many individuals take just 25mcg or 37.5mcg. I was originally diagnosed with Hashimoto's thyroiditis with TSH of 3.8, and Anti-TPO of 800 (0-50). I was put on 50mcg, and it lowered my TSH to a range of 0.80 -1.20 consistently. After 1 year on levothyroxine my TSH jumped to the 1.5-1.8 range, and my dose was increased to 75mcg. After a couple months at this higher dose my TSH dropped too low (to 0.60) and my doctor immediately switched me back to the 50mcg dose. These changes were a learning experience. When I initially began taking levothyroxine (2006) I took it 1st thing in the morning on an empty stomach and did not eat for 1 full hour after taking it. As time went on, I stopped fasting for the full hour. Some days i waited 45 minutes to eat while other days I might only wait 30 minutes. This caused me to need the higher 75mcg dose, as eating sooner was impairing the absorption rate of the medication. But when I began taking it regulary with a full 1 hour before food - the 75mcg dose was too much - thus the low 0.60 TSH measurement. Note I'm 6-0 tall, and weigh 180. So a lower dose works well for me as someone with only mild thyroid function impairment (TSH 3.8 without meds). Someone like NSM, who is 6-0, but weighs 300 lbs, may need an equal or higher dose to produce a similar effect, despite having a less significant impairment of thyroid function (TSH 2.7). Here is a link to a study showing correlation between dosage and body mass index. Note these patients had their entire thyroid removed due to thyroid cancer (total thyroidectomy) - so they have 100% impairment, as opposed to NSM and myself who only have mild impairment of our thyroid function. So it is logical that they would need much higher doses, likely 2x to 3x higher than our 50mcg doses. [URL]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658157/[/URL] "The conventional method of thyroid replacement therapy involved an empiric dose of 100-150 micrograms per day. Following this regimen, between 21-37% of patients attained a euthyroid state at initial follow up." Euthyroid definition = the state of having normal thyroid function (or normal Thyroid hormone levels as a result of thyroid hormone replacement via medication (synthroid, levothyroxine, etc.) Note - we are all learning here - and I do not have all the answers, I was just concerned that some people reading Chris's comment "Wow, its only 50mcg" might interpret that incorrectly. Please correct me if I misunderstood anything. All the best, John [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Finally Got my Full Panel...Way Low Testosterone
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