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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Finally found reason for my ED
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<blockquote data-quote="madman" data-source="post: 198485" data-attributes="member: 13851"><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/age-related-ed-how-to-prevent-it-and-manage-it.22361/[/URL]</p><p></p><p><strong>Etiology of ARED</strong></p><p></p><p>All patients with ED will have as their primary cause either a psychological or a physiological reason. <u><em><strong>All forms of physiological ED other than what is due to a structural anomaly such as a chordee can be relegated to either a vasculogenic, neurogenic and/or a hormonal cause</strong></em></u><strong><em>. <u>When men of various ages from 18 to 80 years are studied to determine the cause of their ED, the most common etiology identified regardless of age is vasculogenic, specifically CVOD (17,18). This high prevalence of CVOD, when compared to that of arterial disease (or defective inflow of blood into the penis), is most striking in the younger population i.e., in men younger than 40 years of age </u>(18,19).</em></strong> However, once middle age begins to set in and the onset of hypertension and diabetes mellitus and other middle-age maladies become more prevalent, the incidence of arterial disease as a cause of ED begins to follow suit (20).</p><p></p><p>Nevertheless, despite this increase in the incidence of arterial disease as men age, <strong><u><em>CVOD or venous leakage can still be identified in about 67% to 75% of men complaining of ED, regardless of whether they are young, middle-aged, or elderly</em></u><em> (17).</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Conclusions</strong></p><p><strong></strong></p><p><strong><u><em>The most common cause of ED, regardless of the age of the patient, is vasculogenic due to CVOD or venous leakage</em></u><em>.</em></strong> Pathologically, this is due to aging-related apoptosis of the corporal SMC similar to what is believed to also occur in the media of the peripheral vasculature.<strong><em> <u>The apoptotic process in the penis appears to begin early in a man’s life and can be first identified by the increase in the refractory period most men will experience usually sometime around their 3rd decade of life</u>. <u>The progression of this increase in the refractory period over time will reach a stage, depending on the patient’s genetics and co-morbidities, where maintenance of the erection becomes problematic, and symptomatic ED is apparent</u>.</em></strong> In response, the SMC begins to fight the oxidative stress and apoptosis associated with these aging-related changes by producing NO from iNOS. <strong><u><em>Preliminary data suggest that products that upregulate this NO-producing pathway and/or pharmacologically release NO, and/or protect its product, cGMP, show promise in halting or reversing the cellular changes associated with this aging process</em></u><em>.</em></strong> It remains to be determined whether such therapy will also be found to be effective on similar aging-related changes that occur in the media of the peripheral vasculature.</p></blockquote><p></p>
[QUOTE="madman, post: 198485, member: 13851"] [URL unfurl="true"]https://www.excelmale.com/forum/threads/age-related-ed-how-to-prevent-it-and-manage-it.22361/[/URL] [B]Etiology of ARED[/B] All patients with ED will have as their primary cause either a psychological or a physiological reason. [U][I][B]All forms of physiological ED other than what is due to a structural anomaly such as a chordee can be relegated to either a vasculogenic, neurogenic and/or a hormonal cause[/B][/I][/U][B][I]. [U]When men of various ages from 18 to 80 years are studied to determine the cause of their ED, the most common etiology identified regardless of age is vasculogenic, specifically CVOD (17,18). This high prevalence of CVOD, when compared to that of arterial disease (or defective inflow of blood into the penis), is most striking in the younger population i.e., in men younger than 40 years of age [/U](18,19).[/I][/B] However, once middle age begins to set in and the onset of hypertension and diabetes mellitus and other middle-age maladies become more prevalent, the incidence of arterial disease as a cause of ED begins to follow suit (20). Nevertheless, despite this increase in the incidence of arterial disease as men age, [B][U][I]CVOD or venous leakage can still be identified in about 67% to 75% of men complaining of ED, regardless of whether they are young, middle-aged, or elderly[/I][/U][I] (17).[/I] Conclusions [U][I]The most common cause of ED, regardless of the age of the patient, is vasculogenic due to CVOD or venous leakage[/I][/U][I].[/I][/B] Pathologically, this is due to aging-related apoptosis of the corporal SMC similar to what is believed to also occur in the media of the peripheral vasculature.[B][I] [U]The apoptotic process in the penis appears to begin early in a man’s life and can be first identified by the increase in the refractory period most men will experience usually sometime around their 3rd decade of life[/U]. [U]The progression of this increase in the refractory period over time will reach a stage, depending on the patient’s genetics and co-morbidities, where maintenance of the erection becomes problematic, and symptomatic ED is apparent[/U].[/I][/B] In response, the SMC begins to fight the oxidative stress and apoptosis associated with these aging-related changes by producing NO from iNOS. [B][U][I]Preliminary data suggest that products that upregulate this NO-producing pathway and/or pharmacologically release NO, and/or protect its product, cGMP, show promise in halting or reversing the cellular changes associated with this aging process[/I][/U][I].[/I][/B] It remains to be determined whether such therapy will also be found to be effective on similar aging-related changes that occur in the media of the peripheral vasculature. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Finally found reason for my ED
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