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Health & Wellness
Female sex hormone helps insulin cross blood vessel lining into muscles, lowering glucose
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<blockquote data-quote="madman" data-source="post: 272327" data-attributes="member: 13851"><p><strong><em>*The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2 diabetes</em></strong></p><p></p><p><em><strong>*Although the metabolic effects of estrogen on muscle and fat tissue have been well documented, its effect on endothelial cells, which line blood vessels, was unknown.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<em><strong>These experiments showed that in both sexes, the estrogen receptor plays a critical role in endothelial cells to lower blood glucose.</strong></em></strong></em></p><p><em><strong><em><strong></strong></em></strong></em></p><p><em><strong><em><strong>*<em><strong>A closer look showed that a protein known as sorting nexin 5 (SNX5) plays a key role in this process. The researchers showed that using a genetic technique to turn off this protein in endothelial cells caused the same loss of estrogen’s ability to stimulate insulin transport as deleting estrogen receptors.</strong></em></strong></em></strong></em></p><p><em><strong><em><strong><em><strong></strong></em></strong></em></strong></em></p><p><em><strong><em><strong><em><strong>*T<em><strong>hese findings indicate that in both males and females, <u>estrogen’s action on endothelial cells is critical for getting insulin to skeletal muscles, where it lowers glucose</u>. Further work is needed to determine where estrogen-promoting insulin transport into muscles comes from in males</strong>.</em></strong></em></strong></em></strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 272327, member: 13851"] [B][I]*The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2 diabetes[/I][/B] [I][B]*Although the metabolic effects of estrogen on muscle and fat tissue have been well documented, its effect on endothelial cells, which line blood vessels, was unknown. *[I][B]These experiments showed that in both sexes, the estrogen receptor plays a critical role in endothelial cells to lower blood glucose. *[I][B]A closer look showed that a protein known as sorting nexin 5 (SNX5) plays a key role in this process. The researchers showed that using a genetic technique to turn off this protein in endothelial cells caused the same loss of estrogen’s ability to stimulate insulin transport as deleting estrogen receptors. *T[I][B]hese findings indicate that in both males and females, [U]estrogen’s action on endothelial cells is critical for getting insulin to skeletal muscles, where it lowers glucose[/U]. Further work is needed to determine where estrogen-promoting insulin transport into muscles comes from in males[/B].[/I][/B][/I][/B][/I][/B][/I] [/QUOTE]
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Female sex hormone helps insulin cross blood vessel lining into muscles, lowering glucose
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