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ExcelFemale
HRT in Women
Female Hormone List and Functions
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<blockquote data-quote="Nelson Vergel" data-source="post: 260015" data-attributes="member: 3"><p><h4>Summary</h4><p>In this podcast episode, Dr. Joanne Manson discusses the Women's Health Initiative study, which examined hormone replacement therapy (HRT) in women. The study aimed to determine whether HRT could prevent chronic diseases, including heart disease and cognitive decline. Observational studies had shown potential benefits, but a randomized clinical trial was needed to establish causality.</p><p></p><h4>Highlights</h4> <ul> <li data-xf-list-type="ul">️ Dr. Joanne Manson, a leading expert in women's health, was one of the principal investigators in the Women's Health Initiative study.</li> <li data-xf-list-type="ul">Observational studies suggested that HRT might reduce heart disease, cognitive decline, and mortality rates in women.</li> <li data-xf-list-type="ul">The Women's Health Initiative aimed to test HRT's preventive effects on chronic diseases through a randomized clinical trial.</li> <li data-xf-list-type="ul">The most common HRT formulations in the 90s were conjugated estrogen with and without medroxyprogesterone acetate, tailored to women with and without a uterus, respectively.</li> <li data-xf-list-type="ul">Women in the observational studies tended to be of higher socioeconomic status and health conscious, which could have influenced the results.</li> <li data-xf-list-type="ul">️ The average age of women in the Women's Health Initiative was around 63, more than a decade after menopause onset, whereas women in observational studies were typically in early menopause.</li> </ul><p>Please note that the transcription provided only covers a part of the podcast, and the full discussion with Dr. Joanne Manson may contain more comprehensive insights.</p><p></p><p>[MEDIA=youtube]8bRuzA-qd0s[/MEDIA]</p><p></p><p>JoAnn Manson is a world-renowned endocrinologist, epidemiologist, and Principal Investigator for the Women’s Health Initiative (WHI). In this episode, she dives deep into the WHI to explain the study design, primary outcome, confounding factors, and nuanced benefits and risks of hormone replacement therapy (HRT). JoAnn reflects on how a misinterpretation of the results, combined with sensationalized headlines regarding an elevated risk of breast cancer, led to a significant shift in the perception and utilization of HRT. From there, they take a closer look at the breast cancer data to separate fact from fiction. Additionally, JoAnn gives her take on how one should weigh the risks and benefits of HRT and concludes with a discussion on how physicians can move towards better HRT practices. We discuss: Intro [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=0s" target="_blank">0:00</a>] The Women’s Health Initiative: the original goal of the study, hormone formulations used, and potential confounders [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=255s" target="_blank">4:15</a>]; Study design of the Women’s Health Initiative, primary outcome, and more [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=960s" target="_blank">16:00</a>]; JoAnn’s personal hypothesis about the ability of hormone replacement therapy to reduce heart disease risk prior to the WHI [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=1605s" target="_blank">26:45</a>]; The relationship between estrogen and breast cancer [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=1845s" target="_blank">30:45</a>]; Why the WHI study was stopped early, and the dramatic change in the perception and use of HRT due to the alleged increase in breast cancer risk [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=2250s" target="_blank">37:30</a>]; What Peter finds most troubling about the mainstream view of HRT and a more nuanced look at the benefits and risks of HRT [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=2715s" target="_blank">45:15</a>]; HRT and bone health [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=3360s" target="_blank">56:00</a>]; The importance of timing when it comes to HRT, the best use cases, and advice on finding a clinician [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=3570s" target="_blank">59:30</a>]; A discussion on the potential impact of HRT on mortality and a thought experiment on a long-duration use of HRT [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=3795s" target="_blank">1:03:15</a>]; Moving toward better HRT practices, and the need for more studies [<a href="https://www.youtube.com/watch?v=8bRuzA-qd0s&t=4200s" target="_blank">1:10:00</a>]; and More.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 260015, member: 3"] [HEADING=3]Summary[/HEADING] In this podcast episode, Dr. Joanne Manson discusses the Women's Health Initiative study, which examined hormone replacement therapy (HRT) in women. The study aimed to determine whether HRT could prevent chronic diseases, including heart disease and cognitive decline. Observational studies had shown potential benefits, but a randomized clinical trial was needed to establish causality. [HEADING=3]Highlights[/HEADING] [LIST] [*]️ Dr. Joanne Manson, a leading expert in women's health, was one of the principal investigators in the Women's Health Initiative study. [*]Observational studies suggested that HRT might reduce heart disease, cognitive decline, and mortality rates in women. [*]The Women's Health Initiative aimed to test HRT's preventive effects on chronic diseases through a randomized clinical trial. [*]The most common HRT formulations in the 90s were conjugated estrogen with and without medroxyprogesterone acetate, tailored to women with and without a uterus, respectively. [*]Women in the observational studies tended to be of higher socioeconomic status and health conscious, which could have influenced the results. [*]️ The average age of women in the Women's Health Initiative was around 63, more than a decade after menopause onset, whereas women in observational studies were typically in early menopause. [/LIST] Please note that the transcription provided only covers a part of the podcast, and the full discussion with Dr. Joanne Manson may contain more comprehensive insights. [MEDIA=youtube]8bRuzA-qd0s[/MEDIA] JoAnn Manson is a world-renowned endocrinologist, epidemiologist, and Principal Investigator for the Women’s Health Initiative (WHI). In this episode, she dives deep into the WHI to explain the study design, primary outcome, confounding factors, and nuanced benefits and risks of hormone replacement therapy (HRT). JoAnn reflects on how a misinterpretation of the results, combined with sensationalized headlines regarding an elevated risk of breast cancer, led to a significant shift in the perception and utilization of HRT. From there, they take a closer look at the breast cancer data to separate fact from fiction. Additionally, JoAnn gives her take on how one should weigh the risks and benefits of HRT and concludes with a discussion on how physicians can move towards better HRT practices. We discuss: Intro [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=0s']0:00[/URL]] The Women’s Health Initiative: the original goal of the study, hormone formulations used, and potential confounders [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=255s']4:15[/URL]]; Study design of the Women’s Health Initiative, primary outcome, and more [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=960s']16:00[/URL]]; JoAnn’s personal hypothesis about the ability of hormone replacement therapy to reduce heart disease risk prior to the WHI [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=1605s']26:45[/URL]]; The relationship between estrogen and breast cancer [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=1845s']30:45[/URL]]; Why the WHI study was stopped early, and the dramatic change in the perception and use of HRT due to the alleged increase in breast cancer risk [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=2250s']37:30[/URL]]; What Peter finds most troubling about the mainstream view of HRT and a more nuanced look at the benefits and risks of HRT [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=2715s']45:15[/URL]]; HRT and bone health [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=3360s']56:00[/URL]]; The importance of timing when it comes to HRT, the best use cases, and advice on finding a clinician [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=3570s']59:30[/URL]]; A discussion on the potential impact of HRT on mortality and a thought experiment on a long-duration use of HRT [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=3795s']1:03:15[/URL]]; Moving toward better HRT practices, and the need for more studies [[URL='https://www.youtube.com/watch?v=8bRuzA-qd0s&t=4200s']1:10:00[/URL]]; and More. [/QUOTE]
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ExcelFemale
HRT in Women
Female Hormone List and Functions
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