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That is a great question and one I have gone over many times in my head. I came to the conclusion that it was either one of the two things you suggested - either placebo, or maybe I very briefly entered a sweet spot. Another thought I've had is that the basis for my "feeling great" comment was based on having a high energy day in the gym shortly after taking the AI. But those days come and go seemingly at random so maybe it had nothing to do with the AI.


A few things I can say for sure were not placebo were some of the negative effects. Mentally, I was truly expecting to have better libido/erectile function - the opposite occurred. I had heard about people experiencing joint pain, etc from AIs - I was aware of that side effect but did not experience it. Additionally, I had never heard of anyone saying that an AI made them feel dumb mentally or feel slightly depressed - and those for me were the worst (and most surprising) side effects.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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