I think that’s a good point about people going from injections to oral, and it would take some time to adjust to daily rollercoasters while also not being elevated more throughout the week. However, I also think that the term “absurdly high” is pretty subjective, and sitting at or slightly above the top of the reference range isn’t necessarily a bad thing. If a person takes care of themselves with diet, exercise, and sleep.. then I’d say being on the higher end is probably a better thing. It’s definitely preferential for building muscle and bone density, which is very important for longterm health. You are correct though, that being too amped up constantly is not good…but I’d say that is easy to identify by sleep issues, not necessarily just based on what the levels are. In other words, if you’re sitting above the top of the range 24/7 but sleeping well then your body is adapted to the environment and won’t suffer from the negative of poor sleep. That’s just one example, but applies to lots of other areas like anxiety or hematocrit. If hematocrit is slightly elevated but all other markers look good then the body is well-adjusted to the levels and the hematocrit would not be a concern. But yes, obviously there are things to watch out for when it comes to injections. At the same time though, there are unique concerns that are introduced by oral administration of testosterone that wouldn’t apply as much when it comes to injections.
But again, I’d say you are correct that it’s quite possible many people could benefit from oral test. And it’s probable some people would even prefer that route. The main thing would be to know the pros and cons of whichever path you take, and monitoring/adjusting accordingly. Either way, I say the more options the better. And I’m sure we can all agree that it’s a good thing research is focusing on this front so that we can continue to improve understanding and options going forward.