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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Featured Science from ENDO 2020
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<blockquote data-quote="madman" data-source="post: 175945" data-attributes="member: 13851"><p><span style="font-size: 26px"><strong>Better controlled diabetes is associated with preserved cognitive function following stroke</strong></span></p><p></p><p><span style="color: rgb(184, 49, 47)">Better glucose control can help people with diabetes who have a common type of stroke to preserve their cognitive function,</span> according to a study accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting. The <a href="https://www.endocrine.org/-/media/endocrine/files/endo2020/abstracts/cukierman-yaffe-abstract.pdf" target="_blank">abstract</a> will be published in a special supplemental issue of the <em>Journal of the Endocrine Society</em>. </p><p></p><p><strong><span style="color: rgb(184, 49, 47)">MON-636: </span>The Relationship Between Glucose Control & Cognitive Function in People with Diabetes After a Lacunar Stroke </strong></p><p><strong></strong></p><p><strong>Background & Objective:</strong> Both lacunar strokes and diabetes are risk factors for dementia and cognitive dysfunction. Thus, elucidating modifiable risk factors for cognitive dysfunction in people with type 2 diabetes who experienced a lacunar infarct has large public health implications. One such factor may be glycemic status, as measured by glycosylated hemoglobin (A1C). Thus, the aim of this study was to assess the relationship between A1C and cognitive function in people with diabetes after a lacunar stroke. Research Design & </p><p></p><p><strong>Methods:</strong> The effect of baseline and follow-up A1C on the baseline and the change in Cognitive Assessment Screening Instrument (CASI) score over time among participants with a median of 2 cognitive assessments (range 1-5) was examined in of 942 individuals with diabetes and a lacunar stroke who participated in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial (ClinicalTrials.gov number, NCT00059306). </p><p></p><p><strong>Results: </strong>Every 1 % higher baseline A1C was associated with a 0.06 lower standardized CASI z-score (95% CI -0.101, -0.018). Higher baseline A1C values were associated with lower CASI z-score over time (p for interaction=0.037). A 1% increase in A1C over time, corresponded with a CASI score decrease of 0.021 (95% CI -0.0043, -0.038) during follow-up. All these remained statistically significant after adjustment for age, sex, education, race, depression, hypertension, hyperlipidemia, BMI, CVD, OSA, diabetic retinopathy, nephropathy insulin use and White Matter Abnormalities. </p><p></p><p><strong>Conclusion:</strong> <span style="color: rgb(184, 49, 47)">This analysis of 942 individuals with diabetes after a lacunar stroke demonstrates a relationship between A1C and change in cognitive scores over time. Intervention studies are needed in order to delineate if better glucose control could slow the rate of cognitive decline in this high risk population. </span></p></blockquote><p></p>
[QUOTE="madman, post: 175945, member: 13851"] [SIZE=26px][B]Better controlled diabetes is associated with preserved cognitive function following stroke[/B][/SIZE] [COLOR=rgb(184, 49, 47)]Better glucose control can help people with diabetes who have a common type of stroke to preserve their cognitive function,[/COLOR] according to a study accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting. The [URL='https://www.endocrine.org/-/media/endocrine/files/endo2020/abstracts/cukierman-yaffe-abstract.pdf']abstract[/URL] will be published in a special supplemental issue of the [I]Journal of the Endocrine Society[/I]. [B][COLOR=rgb(184, 49, 47)]MON-636: [/COLOR]The Relationship Between Glucose Control & Cognitive Function in People with Diabetes After a Lacunar Stroke Background & Objective:[/B] Both lacunar strokes and diabetes are risk factors for dementia and cognitive dysfunction. Thus, elucidating modifiable risk factors for cognitive dysfunction in people with type 2 diabetes who experienced a lacunar infarct has large public health implications. One such factor may be glycemic status, as measured by glycosylated hemoglobin (A1C). Thus, the aim of this study was to assess the relationship between A1C and cognitive function in people with diabetes after a lacunar stroke. Research Design & [B]Methods:[/B] The effect of baseline and follow-up A1C on the baseline and the change in Cognitive Assessment Screening Instrument (CASI) score over time among participants with a median of 2 cognitive assessments (range 1-5) was examined in of 942 individuals with diabetes and a lacunar stroke who participated in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial (ClinicalTrials.gov number, NCT00059306). [B]Results: [/B]Every 1 % higher baseline A1C was associated with a 0.06 lower standardized CASI z-score (95% CI -0.101, -0.018). Higher baseline A1C values were associated with lower CASI z-score over time (p for interaction=0.037). A 1% increase in A1C over time, corresponded with a CASI score decrease of 0.021 (95% CI -0.0043, -0.038) during follow-up. All these remained statistically significant after adjustment for age, sex, education, race, depression, hypertension, hyperlipidemia, BMI, CVD, OSA, diabetic retinopathy, nephropathy insulin use and White Matter Abnormalities. [B]Conclusion:[/B] [COLOR=rgb(184, 49, 47)]This analysis of 942 individuals with diabetes after a lacunar stroke demonstrates a relationship between A1C and change in cognitive scores over time. Intervention studies are needed in order to delineate if better glucose control could slow the rate of cognitive decline in this high risk population.[B] [/B][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Featured Science from ENDO 2020
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