ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Featured Science from ENDO 2020
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 175943" data-attributes="member: 13851"><p><span style="font-size: 26px"><strong>Loss of gland in eyelids may be a biomarker for elevated blood glucose in diabetes</strong></span></p><p></p><p><span style="color: rgb(184, 49, 47)">In patients with diabetes, loss of the gland that helps lubricate the eye may be a sign of elevated blood glucose levels,</span> according to research accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting. The <a href="https://www.endocrine.org/-/media/endocrine/files/endo2020/abstracts/momen-wu-abstract.pdf" target="_blank">study</a> will be published in a special supplemental section of the <em>Journal of the Endocrine Society</em>.</p><p></p><p><span style="color: rgb(184, 49, 47)">Meibomian glands in the eyelid play a role in tear film production and tear film stabilization. </span></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">MON-704:</span> Tear Glands and the Diabetic Patient: Is It a Biomarker? </strong></p><p><strong></strong></p><p><strong>Background:</strong> Tear glands in the eyelids, meibomian glands, play a role in tear film production and tear film stabilization. Diabetic patients often complain of dry eye and eye pain. Recently, there are new infrared (820nm) photography techniques to image meibomian glands easily in patients. </p><p></p><p><strong>Purpose:</strong> To study meibomian glands in diabetic patients with dry eye. </p><p></p><p><strong>Methods:</strong> A retrospective chart review (2017-2019) of Type 2 Diabetes Mellitus (T2DM) patients and non-diabetic patients with the diagnosis of "dry eye" in EHR (eClinicalworks, Westborough, MA ) was performed. Infrared eyelid imaging (820 nm wavelength, Heidelberg Spectralis, Heidelberg, Germany) was taken. T2DM: Inclusion criteria: 1) HbA1c of > 5.7% who also had infrared eyelid imaging performed + 4 weeks of their HbA1c lab test results; 2) the percentage loss of meibomian glands for each eye, then averaged, for each patient. Control: Inclusion criteria: 1) non-diabetic patients; 2) HbA1c lab test results; 3) infrared eyelid imaging was performed; 4) percentage loss of meibomian glands was calculated for each eye, then averaged per patient. Exclusion criteria for both T2DM and Controls: younger than the age of 18 years old, older than 90 years old, no glaucoma topical medications, no eyelid surgery, no corneal surgery, no conjunctival surgery. </p><p></p><p><strong>Results:</strong> n=120 patients, Avg Age=69.6 years (sd=15.1, range 23-89 years). Diabetic patients: n=60 patients, Male=30, Female=30, Avg Age=65.1 years (sd=11.50, med=65.5, range 36-85 years). Controls: n=60 patients, Male=37, Female=23, Avg Age=54.1 years (sd=16.4, med=56.5, range 23-89 years). Meibomian gland loss: Diabetics=51.54%, Controls=11.29% (p<0.0001, t-test). Of the 60 DM patients: 35/37 pts with HbA1c > 6.6% had greater loss of meibomian glands (>40%), compared to 12/23 DM patients with HbA1c < 6.5%, p=0.0001. </p><p></p><p><strong>Discussion: </strong>Loss of meibomian glands in diabetic patients have been recently investigated; however, its relationship to HbA1c as a possible biomarker has not been widely discussed in literature. In this small study, loss of meibomian glands occur more frequently with elevated HbA1c, perhaps due to microischemia of the eyelids, thereby resulting in loss of meibomian glands. </p><p></p><p><strong>Conclusion:</strong> <span style="color: rgb(184, 49, 47)">Loss of meibomian glands may suggest a need for HbA1c testing and further monitoring of the patient's diabetic condition.</span> <span style="color: rgb(44, 130, 201)">Infrared imaging of the eyelid may be useful in characterizing dry eye in diabetic patients. </span></p></blockquote><p></p>
[QUOTE="madman, post: 175943, member: 13851"] [SIZE=26px][B]Loss of gland in eyelids may be a biomarker for elevated blood glucose in diabetes[/B][/SIZE] [COLOR=rgb(184, 49, 47)]In patients with diabetes, loss of the gland that helps lubricate the eye may be a sign of elevated blood glucose levels,[/COLOR] according to research accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting. The [URL='https://www.endocrine.org/-/media/endocrine/files/endo2020/abstracts/momen-wu-abstract.pdf']study[/URL] will be published in a special supplemental section of the [I]Journal of the Endocrine Society[/I]. [COLOR=rgb(184, 49, 47)]Meibomian glands in the eyelid play a role in tear film production and tear film stabilization. [/COLOR] [B][COLOR=rgb(184, 49, 47)]MON-704:[/COLOR] Tear Glands and the Diabetic Patient: Is It a Biomarker? Background:[/B] Tear glands in the eyelids, meibomian glands, play a role in tear film production and tear film stabilization. Diabetic patients often complain of dry eye and eye pain. Recently, there are new infrared (820nm) photography techniques to image meibomian glands easily in patients. [B]Purpose:[/B] To study meibomian glands in diabetic patients with dry eye. [B]Methods:[/B] A retrospective chart review (2017-2019) of Type 2 Diabetes Mellitus (T2DM) patients and non-diabetic patients with the diagnosis of "dry eye" in EHR (eClinicalworks, Westborough, MA ) was performed. Infrared eyelid imaging (820 nm wavelength, Heidelberg Spectralis, Heidelberg, Germany) was taken. T2DM: Inclusion criteria: 1) HbA1c of > 5.7% who also had infrared eyelid imaging performed + 4 weeks of their HbA1c lab test results; 2) the percentage loss of meibomian glands for each eye, then averaged, for each patient. Control: Inclusion criteria: 1) non-diabetic patients; 2) HbA1c lab test results; 3) infrared eyelid imaging was performed; 4) percentage loss of meibomian glands was calculated for each eye, then averaged per patient. Exclusion criteria for both T2DM and Controls: younger than the age of 18 years old, older than 90 years old, no glaucoma topical medications, no eyelid surgery, no corneal surgery, no conjunctival surgery. [B]Results:[/B] n=120 patients, Avg Age=69.6 years (sd=15.1, range 23-89 years). Diabetic patients: n=60 patients, Male=30, Female=30, Avg Age=65.1 years (sd=11.50, med=65.5, range 36-85 years). Controls: n=60 patients, Male=37, Female=23, Avg Age=54.1 years (sd=16.4, med=56.5, range 23-89 years). Meibomian gland loss: Diabetics=51.54%, Controls=11.29% (p<0.0001, t-test). Of the 60 DM patients: 35/37 pts with HbA1c > 6.6% had greater loss of meibomian glands (>40%), compared to 12/23 DM patients with HbA1c < 6.5%, p=0.0001. [B]Discussion: [/B]Loss of meibomian glands in diabetic patients have been recently investigated; however, its relationship to HbA1c as a possible biomarker has not been widely discussed in literature. In this small study, loss of meibomian glands occur more frequently with elevated HbA1c, perhaps due to microischemia of the eyelids, thereby resulting in loss of meibomian glands. [B]Conclusion:[/B] [COLOR=rgb(184, 49, 47)]Loss of meibomian glands may suggest a need for HbA1c testing and further monitoring of the patient's diabetic condition.[/COLOR] [COLOR=rgb(44, 130, 201)]Infrared imaging of the eyelid may be useful in characterizing dry eye in diabetic patients. [/COLOR] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
X (Twitter)
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Featured Science from ENDO 2020
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top