FDA review panel recommends approval of PTH therapy for hypoparathyroidism

Nelson Vergel

Founder, ExcelMale.com
The drug, which was previously approved for osteoporosis treatment in Europe from 2006 to 2013, met the primary endpoints of decreased need for vitamin D and calcium in patients with hypoparathyroidism, as was shown by the manufacturer in their pivotal trial.

“A once-a-day injection provided a sustained increase in serum calcium lasting 24 hours, a decrease in urinary calcium excretion for 12 to 16 hours, the conversion of vitamin D to active vitamin D and a decrease in serum phosphate,” Hjalmar Lagast, MD, of NPS Pharmaceuticals, the drug sponsor and manufacturer, said during his presentation.

http://www.healio.com/endocrinology...pproval-of-pth-therapy-for-hypoparathyroidism
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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