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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
FDA approved, discontinued androgens (FDA orange book)
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<blockquote data-quote="Nelson Vergel" data-source="post: 258884" data-attributes="member: 3"><p>I am so happy women now have an OTC option!</p><p></p><p>The picture about oxandrolone is not completely clear. All US manufacturers have stopped making it. The FDA information is erroneous since it mentions hepatotoxicity. We know oxymetholone definitely has caused that issue when people use it for long periods of time. But oxandrolone has not shown that type of safety signal.</p><p></p><p>From ChatGPT:</p><p></p><p></p><p>Oxymetholone and Oxandrolone are both oral anabolic steroids. They are C-17 alpha-alkylated, a structural alteration that allows them to survive oral ingestion by bypassing the liver and entering the bloodstream. Both substances are known to exert their effects on muscle tissue, leading to increased muscle mass. However, they also have distinct effects on the liver that are important to consider.</p><p></p><p>1. Oxymetholone</p><p></p><p>Oxymetholone, sold under the brand names Anadrol and Anapolon among others, is an androgen and anabolic steroid (AAS) medication primarily used to treat anemia. It is also used to treat osteoporosis, HIV/AIDS wasting syndrome, and to promote weight gain and muscle growth in certain situations.</p><p></p><p>Due to its potent anabolic effects, Oxymetholone is commonly used illicitly by bodybuilders and athletes. However, it has several hepatic side effects that are of concern. The most notable of these is hepatotoxicity.</p><p></p><p>Oxymetholone can cause liver damage, which is usually reversible after discontinuation of the drug. Clinical studies have reported a strong association between oxymetholone usage and the development of liver abnormalities such as peliosis hepatis (blood-filled cavities in the liver), cholestasis (reduction or stoppage of bile flow), and liver tumors, including hepatocellular carcinoma (Alhadad A., 2019).</p><p></p><p>One case-control study demonstrated the incidence of hepatic tumors in bodybuilders who abused anabolic steroids, including oxymetholone (Socas L., 2005). The nature of these tumors varied from benign adenomas to hepatocellular carcinoma.</p><p></p><p>Reference:</p><p></p><p>Alhadad A. A., 2019. Acute kidney injury and cardiomyopathy due to oxymetholone abuse. Case reports in nephrology, 2019.</p><p></p><p>Socas L., 2005. Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and a review of the literature. British journal of sports medicine, 39(5), pp.e27.</p><p></p><p></p><p>2. Oxandrolone</p><p></p><p>Oxandrolone, sold under the brand names Oxandrin and Anavar, among others, is an androgen and anabolic steroid (AAS) medication which is used to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns, to treat bone pain associated with osteoporosis, and to aid in the development of girls with Turner syndrome.</p><p></p><p>Compared to oxymetholone, oxandrolone has a more favorable safety profile. It is less hepatotoxic and is less likely to promote virilization (development of male physical characteristics) in women.</p><p></p><p>Although oxandrolone is classified as a Schedule III controlled substance due to potential for misuse and abuse, it does not appear to have the same level of hepatotoxicity as oxymetholone. Most studies on oxandrolone have demonstrated mild, transient elevations in liver enzymes, but these generally return to normal upon discontinuation of the drug. There are very few case reports of serious hepatic side effects from oxandrolone, and those that do exist often involve other complicating factors such long term use and higher doses (Demling RH., 1999).</p><p></p><p>However, it's important to remember that "less hepatotoxic" does not mean "non-hepatotoxic." Any long term usage of oral anabolic steroids should be done under the supervision of a healthcare provider, who can monitor liver function and adjust dosages as necessary.</p><p></p><p>Reference:</p><p></p><p>Demling RH., 1999. Oxandrolone, an anabolic steroid, enhances the healing of a cutaneous wound in the rat. Wound Repair and Regeneration, 7(2), pp.97-102.</p><p></p><p>To conclude, both Oxymetholone and Oxandrolone have potential hepatotoxic effects due to their C-17 alpha-alkylated nature. Oxymetholone is associated with a higher risk of serious liver damage, including cholestasis and hepatocellular carcinoma. On the other hand, Oxandrolone seems to have a more favorable safety profile and is associated with mild and usually reversible liver enzyme elevations. However, both should be used under medical supervision, as misuse and overuse can lead to severe hepatic injury.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 258884, member: 3"] I am so happy women now have an OTC option! The picture about oxandrolone is not completely clear. All US manufacturers have stopped making it. The FDA information is erroneous since it mentions hepatotoxicity. We know oxymetholone definitely has caused that issue when people use it for long periods of time. But oxandrolone has not shown that type of safety signal. From ChatGPT: Oxymetholone and Oxandrolone are both oral anabolic steroids. They are C-17 alpha-alkylated, a structural alteration that allows them to survive oral ingestion by bypassing the liver and entering the bloodstream. Both substances are known to exert their effects on muscle tissue, leading to increased muscle mass. However, they also have distinct effects on the liver that are important to consider. 1. Oxymetholone Oxymetholone, sold under the brand names Anadrol and Anapolon among others, is an androgen and anabolic steroid (AAS) medication primarily used to treat anemia. It is also used to treat osteoporosis, HIV/AIDS wasting syndrome, and to promote weight gain and muscle growth in certain situations. Due to its potent anabolic effects, Oxymetholone is commonly used illicitly by bodybuilders and athletes. However, it has several hepatic side effects that are of concern. The most notable of these is hepatotoxicity. Oxymetholone can cause liver damage, which is usually reversible after discontinuation of the drug. Clinical studies have reported a strong association between oxymetholone usage and the development of liver abnormalities such as peliosis hepatis (blood-filled cavities in the liver), cholestasis (reduction or stoppage of bile flow), and liver tumors, including hepatocellular carcinoma (Alhadad A., 2019). One case-control study demonstrated the incidence of hepatic tumors in bodybuilders who abused anabolic steroids, including oxymetholone (Socas L., 2005). The nature of these tumors varied from benign adenomas to hepatocellular carcinoma. Reference: Alhadad A. A., 2019. Acute kidney injury and cardiomyopathy due to oxymetholone abuse. Case reports in nephrology, 2019. Socas L., 2005. Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and a review of the literature. British journal of sports medicine, 39(5), pp.e27. 2. Oxandrolone Oxandrolone, sold under the brand names Oxandrin and Anavar, among others, is an androgen and anabolic steroid (AAS) medication which is used to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns, to treat bone pain associated with osteoporosis, and to aid in the development of girls with Turner syndrome. Compared to oxymetholone, oxandrolone has a more favorable safety profile. It is less hepatotoxic and is less likely to promote virilization (development of male physical characteristics) in women. Although oxandrolone is classified as a Schedule III controlled substance due to potential for misuse and abuse, it does not appear to have the same level of hepatotoxicity as oxymetholone. Most studies on oxandrolone have demonstrated mild, transient elevations in liver enzymes, but these generally return to normal upon discontinuation of the drug. There are very few case reports of serious hepatic side effects from oxandrolone, and those that do exist often involve other complicating factors such long term use and higher doses (Demling RH., 1999). However, it's important to remember that "less hepatotoxic" does not mean "non-hepatotoxic." Any long term usage of oral anabolic steroids should be done under the supervision of a healthcare provider, who can monitor liver function and adjust dosages as necessary. Reference: Demling RH., 1999. Oxandrolone, an anabolic steroid, enhances the healing of a cutaneous wound in the rat. Wound Repair and Regeneration, 7(2), pp.97-102. To conclude, both Oxymetholone and Oxandrolone have potential hepatotoxic effects due to their C-17 alpha-alkylated nature. Oxymetholone is associated with a higher risk of serious liver damage, including cholestasis and hepatocellular carcinoma. On the other hand, Oxandrolone seems to have a more favorable safety profile and is associated with mild and usually reversible liver enzyme elevations. However, both should be used under medical supervision, as misuse and overuse can lead to severe hepatic injury. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
FDA approved, discontinued androgens (FDA orange book)
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