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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Fatigue, Anxiety, Irritability. Changing protocol, trying to stay on TRT, Help needed
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<blockquote data-quote="Cataceous" data-source="post: 185240" data-attributes="member: 38109"><p>1. It's been suggested that higher testosterone levels are associated with action and lower levels with rest and recovery. This would be in line with an argument based on evolution, in which it's inferred that it's advantageous to have higher testosterone in the earlier waking hours. This is best imitated with a propionate injection at first waking. Many, myself included, find that rising testosterone interferes with sleep. An evening injection puts peak testosterone before midnight. So by morning you're significantly lower and falling through mean levels by noon, well out of phase with what's seen naturally.</p><p></p><p>The least natural part of propionate injections is the lack of a more gradual rise in serum testosterone in the early morning hours. Instead you get a much more abrupt rise after waking. But it could be argued that the natural pattern is slower because it has to be, not because it's necessarily better. That is, the signaling through the hypothalamus, pituitary and testicles takes time, as does ramping up production of testosterone.</p><p></p><p>Of course it's perfectly ok to be skeptical, as this isn't hard and settled science. It's a trivial matter to do your own experimentation to see what works best for you. The nice thing about propionate is that changes to dosing stabilize within a few days.</p><p></p><p>2. Subcutaneous injections have slower absorption than intramuscular. So they may help to reduce peak serum levels and raise trough levels. Average levels are about the same for either method. As I mentioned, the simplest way to control the magnitude of the variations is by adding in a longer ester that provides a fairly constant "background" testosterone level.</p><p></p><p>3. In theory, if you split your daily propionate dose into enough separate injections then you can imitate almost any waveform pretty well. If you're only splitting into two then ideally you'd want a smaller one around 2-3 am and a larger one around 5-6 am. But overall this won't mimic a natural rhythm as well as a single dose with two esters.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 185240, member: 38109"] 1. It's been suggested that higher testosterone levels are associated with action and lower levels with rest and recovery. This would be in line with an argument based on evolution, in which it's inferred that it's advantageous to have higher testosterone in the earlier waking hours. This is best imitated with a propionate injection at first waking. Many, myself included, find that rising testosterone interferes with sleep. An evening injection puts peak testosterone before midnight. So by morning you're significantly lower and falling through mean levels by noon, well out of phase with what's seen naturally. The least natural part of propionate injections is the lack of a more gradual rise in serum testosterone in the early morning hours. Instead you get a much more abrupt rise after waking. But it could be argued that the natural pattern is slower because it has to be, not because it's necessarily better. That is, the signaling through the hypothalamus, pituitary and testicles takes time, as does ramping up production of testosterone. Of course it's perfectly ok to be skeptical, as this isn't hard and settled science. It's a trivial matter to do your own experimentation to see what works best for you. The nice thing about propionate is that changes to dosing stabilize within a few days. 2. Subcutaneous injections have slower absorption than intramuscular. So they may help to reduce peak serum levels and raise trough levels. Average levels are about the same for either method. As I mentioned, the simplest way to control the magnitude of the variations is by adding in a longer ester that provides a fairly constant "background" testosterone level. 3. In theory, if you split your daily propionate dose into enough separate injections then you can imitate almost any waveform pretty well. If you're only splitting into two then ideally you'd want a smaller one around 2-3 am and a larger one around 5-6 am. But overall this won't mimic a natural rhythm as well as a single dose with two esters. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Fatigue, Anxiety, Irritability. Changing protocol, trying to stay on TRT, Help needed
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