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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Fatigue, anger, swollen ankles, etc.
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<blockquote data-quote="xqfq" data-source="post: 153766" data-attributes="member: 38167"><p>It's great to hear you were able to resolve some of those issues.</p><p></p><p>I used the "free E2 calculator" spreadsheet to calculate an approximate "free E2" for you, which was 1.11 pg/mL. Range in men is supposedly 0.2 - 1.5 (<a href="https://www.discountedlabs.com/free-estradiol-sensitive" target="_blank">Free Estradiol (Sensitive)</a>). But this calculator /may/ be more accurate using the "standard" E2 test values versus the sensitive, interestingly enough. So if you have a standard E2 reading it may be worth sharing. If you standard E2 is significantly higher and that's a true trough reading of E2, you could maybe be trending into too-high E2 territory, leading to the water retention.</p><p></p><p>Another possibility, without any evidence right now -- and just throwing this out there in case you're looking for paths to tread down to investigate -- is that maybe your progesterone is low relative to your estrogen: <a href="https://www.excelmale.com/forum/threads/could-the-ratio-of-progesterone-to-estradiol-affect-water-retention.19131/" target="_blank">Could the ratio of progesterone to estradiol affect water retention?</a> I'm looking more into this myself soon, and -- again -- there's no evidence as of now that this could be a factor, but I'm just throwing it out there as it could explain water retention with normal E2. Some men have low progesterone even with HCG.</p><p></p><p>Yet another possibility is that HCG itself[1] could be causing the water retention. So you could try removing HCG and seeing if it resolves. Of course, it could be due to extra T/E2 from the HCG, so you may want to try this option last.</p><p></p><p>1. I'm not sure of the mechanism, but I've read a lot of reports of guys having water retention via HCG with normal E2. One possibility is the metabolite of pregnenolone, androstenediol, which binds to the estrogen receptors but is itself not E2. I'm digging into this as well..</p></blockquote><p></p>
[QUOTE="xqfq, post: 153766, member: 38167"] It's great to hear you were able to resolve some of those issues. I used the "free E2 calculator" spreadsheet to calculate an approximate "free E2" for you, which was 1.11 pg/mL. Range in men is supposedly 0.2 - 1.5 ([URL='https://www.discountedlabs.com/free-estradiol-sensitive']Free Estradiol (Sensitive)[/URL]). But this calculator /may/ be more accurate using the "standard" E2 test values versus the sensitive, interestingly enough. So if you have a standard E2 reading it may be worth sharing. If you standard E2 is significantly higher and that's a true trough reading of E2, you could maybe be trending into too-high E2 territory, leading to the water retention. Another possibility, without any evidence right now -- and just throwing this out there in case you're looking for paths to tread down to investigate -- is that maybe your progesterone is low relative to your estrogen: [URL='https://www.excelmale.com/forum/threads/could-the-ratio-of-progesterone-to-estradiol-affect-water-retention.19131/']Could the ratio of progesterone to estradiol affect water retention?[/URL] I'm looking more into this myself soon, and -- again -- there's no evidence as of now that this could be a factor, but I'm just throwing it out there as it could explain water retention with normal E2. Some men have low progesterone even with HCG. Yet another possibility is that HCG itself[1] could be causing the water retention. So you could try removing HCG and seeing if it resolves. Of course, it could be due to extra T/E2 from the HCG, so you may want to try this option last. 1. I'm not sure of the mechanism, but I've read a lot of reports of guys having water retention via HCG with normal E2. One possibility is the metabolite of pregnenolone, androstenediol, which binds to the estrogen receptors but is itself not E2. I'm digging into this as well.. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Fatigue, anger, swollen ankles, etc.
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