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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Fast Metabolizers?
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<blockquote data-quote="Cataceous" data-source="post: 197623" data-attributes="member: 38109"><p>I think you're asking whether the underlying metabolic clearance rate for testosterone—that's independent of SHBG—can change significantly over time due to TRT. I haven't seen research that's explored this directly. I can say that over a period of several years on TRT my underlying clearance rate did not appear to change; I can multiply my testosterone dose rate by a fixed constant to accurately predict the resulting free testosterone at steady state. There's also a study showing that this kind of linearity applies to groups of men taking various doses of testosterone, going as high as 600 mg/week.[<a href="https://www.excelmale.com/forum/threads/response-from-labcorp-about-their-incorrect-unit-usages-for-their-free-testosterone-direct-test.22716/post-194773" target="_blank">R</a>] The treatment period in the study was 20 weeks, so at least in this time frame there was no obvious dose-dependent divergence in underlying testosterone clearance rates.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 197623, member: 38109"] I think you're asking whether the underlying metabolic clearance rate for testosterone—that's independent of SHBG—can change significantly over time due to TRT. I haven't seen research that's explored this directly. I can say that over a period of several years on TRT my underlying clearance rate did not appear to change; I can multiply my testosterone dose rate by a fixed constant to accurately predict the resulting free testosterone at steady state. There's also a study showing that this kind of linearity applies to groups of men taking various doses of testosterone, going as high as 600 mg/week.[[URL='https://www.excelmale.com/forum/threads/response-from-labcorp-about-their-incorrect-unit-usages-for-their-free-testosterone-direct-test.22716/post-194773']R[/URL]] The treatment period in the study was 20 weeks, so at least in this time frame there was no obvious dose-dependent divergence in underlying testosterone clearance rates. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Fast Metabolizers?
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