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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Fail in Testosterone metabolization
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<blockquote data-quote="madman" data-source="post: 184658" data-attributes="member: 13851"><p>Total Teastosterone = <u>Albumin-bound T + SHBG bound T + unbound Free Testosterone</u></p><p></p><p>Bioavailable Testosterone = <u>Albumin bound T + unbound Free Testosterone</u></p><p></p><p></p><p>Although TT is important FT is what truly matters as it is the active unbound fraction of TT responsible for the beneficial effects.</p><p></p><p>Yes, one can have a normal/high-normal TT and experience low-t symptoms if their FT level is low/lowish due to high SHBG.</p><p></p><p>[ATTACH=full]10405[/ATTACH]</p><p><strong>Partitioning of testosterone in the systemic circulation. Circulating testosterone is <span style="color: rgb(26, 188, 156)"><u>bound tightly to</u></span> <span style="color: rgb(26, 188, 156)"><u>SHBG</u></span> <span style="color: rgb(26, 188, 156)">(green = high affinity binding)</span> and <span style="color: rgb(44, 130, 201)"><u>weakly to albumin, orosomucoid (ORM), and CBG </u>(blue = low affinity binding)</span> (<a href="https://www.excelmale.com/forum/javascript%3A;" target="_blank">11</a>). <span style="color: rgb(184, 49, 47)"><u>Only 1% to 4% of circulating testosterone is unbound or free</u>.</span> The combination of free and albumin-bound testosterone is also referred to as the “bioavailable testosterone” fraction. </strong></p><p></p><p>The only way to truly know if your testosterone levels are low is to have your TT/FT tested and it should also include your SHBG as many uninformed doctors would only test TT and do not look at FT let alone SHBG levels.</p><p></p><p>There are many men who have normal TT but low FT due to high SHBG which would lead to one experiencing low-t symptoms.</p><p></p><p>Do you have blood work to post?</p></blockquote><p></p>
[QUOTE="madman, post: 184658, member: 13851"] Total Teastosterone = [U]Albumin-bound T + SHBG bound T + unbound Free Testosterone[/U] Bioavailable Testosterone = [U]Albumin bound T + unbound Free Testosterone[/U] Although TT is important FT is what truly matters as it is the active unbound fraction of TT responsible for the beneficial effects. Yes, one can have a normal/high-normal TT and experience low-t symptoms if their FT level is low/lowish due to high SHBG. [ATTACH type="full" alt="Screenshot (1763).png"]10405[/ATTACH] [B]Partitioning of testosterone in the systemic circulation. Circulating testosterone is [COLOR=rgb(26, 188, 156)][U]bound tightly to[/U][/COLOR][U] [/U][COLOR=rgb(26, 188, 156)][U]SHBG[/U][/COLOR][COLOR=rgb(0, 0, 0)] [/COLOR][COLOR=rgb(26, 188, 156)](green = high affinity binding)[/COLOR] and [COLOR=rgb(44, 130, 201)][U]weakly to albumin, orosomucoid (ORM), and CBG [/U](blue = low affinity binding)[/COLOR] ([URL='https://www.excelmale.com/forum/javascript%3A;']11[/URL]). [COLOR=rgb(184, 49, 47)][U]Only 1% to 4% of circulating testosterone is unbound or free[/U].[/COLOR] The combination of free and albumin-bound testosterone is also referred to as the “bioavailable testosterone” fraction. [/B] The only way to truly know if your testosterone levels are low is to have your TT/FT tested and it should also include your SHBG as many uninformed doctors would only test TT and do not look at FT let alone SHBG levels. There are many men who have normal TT but low FT due to high SHBG which would lead to one experiencing low-t symptoms. Do you have blood work to post? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Fail in Testosterone metabolization
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