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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Experiences of using two methods to measure estradiol in men: E2 (CLIA) Vs E2 (Sensitive)
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<blockquote data-quote="tareload" data-source="post: 150032"><p>Look at these parity plots (as they are typically called). Each point is an individual. E2 immunoassay (non-sensitive) is typically (majority of folks) but not always higher than the LC-MS (sensitive) E2 test. Some of these guys are below the parity line on the plots below. </p><p></p><p>My experience is quite different than Gman86's data above (I admire your systematic data collection). Inflammatory proteins/antibodies in the blood will cause interference on the RIA assay and typically my LCMS E2 runs 50% of the RIA number (for example, 34 pg/mL on the sensitive test vs 69 pg/mL with non-sensitive RIA). Hence, I am typically in range on the LC-MS test and out of range on the RIA. Good luck getting your provider to run both tests head to head (especially in-network). They will most likely have no idea what you are talking about. My in-network provider labels the sensitive test "pediatric estradiol" <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" />. </p><p></p><p>Very easy to do head to head comparison with Defy or with your enlightened cash pay provider. Where do you fall on the plots below if you are in to systematically measuring that type of thing?</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/24334824" target="_blank">Performance of direct estradiol immunoassays with human male serum samples.</a></p><p></p><p>[ATTACH=full]7547[/ATTACH]</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/22423144" target="_blank">Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men.</a></p><p></p><p>[ATTACH=full]7548[/ATTACH]</p></blockquote><p></p>
[QUOTE="tareload, post: 150032"] Look at these parity plots (as they are typically called). Each point is an individual. E2 immunoassay (non-sensitive) is typically (majority of folks) but not always higher than the LC-MS (sensitive) E2 test. Some of these guys are below the parity line on the plots below. My experience is quite different than Gman86's data above (I admire your systematic data collection). Inflammatory proteins/antibodies in the blood will cause interference on the RIA assay and typically my LCMS E2 runs 50% of the RIA number (for example, 34 pg/mL on the sensitive test vs 69 pg/mL with non-sensitive RIA). Hence, I am typically in range on the LC-MS test and out of range on the RIA. Good luck getting your provider to run both tests head to head (especially in-network). They will most likely have no idea what you are talking about. My in-network provider labels the sensitive test "pediatric estradiol" :-). Very easy to do head to head comparison with Defy or with your enlightened cash pay provider. Where do you fall on the plots below if you are in to systematically measuring that type of thing? [URL='https://www.ncbi.nlm.nih.gov/pubmed/24334824']Performance of direct estradiol immunoassays with human male serum samples.[/URL] [ATTACH=full]7547[/ATTACH] [URL='https://www.ncbi.nlm.nih.gov/pubmed/22423144']Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men.[/URL] [ATTACH=full]7548[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Experiences of using two methods to measure estradiol in men: E2 (CLIA) Vs E2 (Sensitive)
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