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Health & Wellness
Excess Iron In The Brain Of PwP And The Role Of Thiamine, Melatonin And Hesperidin In Alleviating This Issue
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<blockquote data-quote="Vince" data-source="post: 262348" data-attributes="member: 843"><p>Excess iron in the brain is thought to be a contributing factor to PD and is known to damage the brain. Iron increases in the brain with age, but even more so in PD. Symptoms of too much iron in the brain include progressive dystonia (a movement disorder resulting in muscular spasms, twisting, and repetitive movements) spasticity, parkinsonism (slurred or slow speech, stiffness of the muscles, slow movement, and visible tremors), inability to coordinate movements (ataxia), neuropsychiatric abnormalities (confusion, disorientation, seizures, stupor, dementia), and eye problems, such as optic atrophy or retinal degeneration. Cerebellar atrophy is common in many cases as discussed in the following article :</p><p></p><p>[URL unfurl="true"]https://rarediseases.info.nih.gov/diseases/11899/neurodegeneration-with-brain-iron-accumulation[/URL]</p><p></p><p>Here is a relevant quote from the article :</p><p></p><p>' Neurodegeneration with brain iron accumulation (NBIA) is a group of inherited neurologic disorders in which iron accumulates in the basal ganglia. Symptoms include progressive dystonia (a movement disorder resulting in muscular spasms, twisting, and repetitive movements) spasticity, parkinsonism (slurred or slow speech, stiffness of the muscles, slow movement, and visible tremors), inability to coordinate movements (ataxia), neuropsychiatric abnormalities (confusion, disorientation, seizures, stupor, dementia), and eye problems, such as optic atrophy or retinal degeneration. Cerebellar atrophy is common in many cases. '</p><p></p><p>The following meta analysis illustrates that iron levels are higher in the brain of PwP :</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101491/[/URL]</p><p></p><p>In this first study melatonin is shown to have protective effects against the damage caused by iron overload :</p><p></p><p>[URL unfurl="true"]https://www.sciencedirect.com/science/article/abs/pii/S1568163722001593[/URL]</p></blockquote><p></p>
[QUOTE="Vince, post: 262348, member: 843"] Excess iron in the brain is thought to be a contributing factor to PD and is known to damage the brain. Iron increases in the brain with age, but even more so in PD. Symptoms of too much iron in the brain include progressive dystonia (a movement disorder resulting in muscular spasms, twisting, and repetitive movements) spasticity, parkinsonism (slurred or slow speech, stiffness of the muscles, slow movement, and visible tremors), inability to coordinate movements (ataxia), neuropsychiatric abnormalities (confusion, disorientation, seizures, stupor, dementia), and eye problems, such as optic atrophy or retinal degeneration. Cerebellar atrophy is common in many cases as discussed in the following article : [URL unfurl="true"]https://rarediseases.info.nih.gov/diseases/11899/neurodegeneration-with-brain-iron-accumulation[/URL] Here is a relevant quote from the article : ' Neurodegeneration with brain iron accumulation (NBIA) is a group of inherited neurologic disorders in which iron accumulates in the basal ganglia. Symptoms include progressive dystonia (a movement disorder resulting in muscular spasms, twisting, and repetitive movements) spasticity, parkinsonism (slurred or slow speech, stiffness of the muscles, slow movement, and visible tremors), inability to coordinate movements (ataxia), neuropsychiatric abnormalities (confusion, disorientation, seizures, stupor, dementia), and eye problems, such as optic atrophy or retinal degeneration. Cerebellar atrophy is common in many cases. ' The following meta analysis illustrates that iron levels are higher in the brain of PwP : [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101491/[/URL] In this first study melatonin is shown to have protective effects against the damage caused by iron overload : [URL unfurl="true"]https://www.sciencedirect.com/science/article/abs/pii/S1568163722001593[/URL] [/QUOTE]
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Excess Iron In The Brain Of PwP And The Role Of Thiamine, Melatonin And Hesperidin In Alleviating This Issue
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