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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Estrogen-It's what makes a real man
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<blockquote data-quote="madman" data-source="post: 234318" data-attributes="member: 13851"><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/does-estradiol-promote-fat-expansion-in-the-absence-of-testosterone.24906/[/URL]</p><p></p><p><strong>Significance and conclusions</strong></p><p><strong></strong></p><p><strong><em>The unique experimental design of this study allowed us to examine the effects of E2 on male fat mass in the absence of testosterone. <u>We refute our hypothesis of a direct E2 effect to reduce fat mass but provide suggestive evidence that, contrary to our hypothesis, E2, without testosterone, may increase, rather than decrease total and regional fat mass over 6 months</u>. <u>While preliminary, these findings provide insights into the biological actions of E2 in men, which may be more complex than traditionally assumed</u>. <u>While work by Finkelstein et al., and others, discussed above, has highlighted the importance of E2 in determining fat distribution and accumulation in combination with testosterone replacement, this RCT suggests E2 might be permissive for actions of androgens in preventing fat accumulation but that E2 itself is not solely responsible for these effects</u>. <u>This insight, if confirmed would be relevant for designing optimal hormone replacement regimens for hypogonadal men</u>. Moreover, E2, albeit in higher doses, is currently under investigation as a sole mode of ADT (59). Given that E2 as a sole mode of ADT reduces testosterone to castrate concentrations, a better understanding of the effects of E2 on fat mass and cardiometabolic risk factors has clinical relevance, particularly since cardiovascular events are a common cause of death in men with early prostate cancer.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 234318, member: 13851"] [URL unfurl="true"]https://www.excelmale.com/forum/threads/does-estradiol-promote-fat-expansion-in-the-absence-of-testosterone.24906/[/URL] [B]Significance and conclusions [I]The unique experimental design of this study allowed us to examine the effects of E2 on male fat mass in the absence of testosterone. [U]We refute our hypothesis of a direct E2 effect to reduce fat mass but provide suggestive evidence that, contrary to our hypothesis, E2, without testosterone, may increase, rather than decrease total and regional fat mass over 6 months[/U]. [U]While preliminary, these findings provide insights into the biological actions of E2 in men, which may be more complex than traditionally assumed[/U]. [U]While work by Finkelstein et al., and others, discussed above, has highlighted the importance of E2 in determining fat distribution and accumulation in combination with testosterone replacement, this RCT suggests E2 might be permissive for actions of androgens in preventing fat accumulation but that E2 itself is not solely responsible for these effects[/U]. [U]This insight, if confirmed would be relevant for designing optimal hormone replacement regimens for hypogonadal men[/U]. Moreover, E2, albeit in higher doses, is currently under investigation as a sole mode of ADT (59). Given that E2 as a sole mode of ADT reduces testosterone to castrate concentrations, a better understanding of the effects of E2 on fat mass and cardiometabolic risk factors has clinical relevance, particularly since cardiovascular events are a common cause of death in men with early prostate cancer.[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Estrogen-It's what makes a real man
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