ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Estrogen crash causing permanent apathy/lethargy - by destroying your dopamine neurons?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="simeoni" data-source="post: 55816" data-attributes="member: 14463"><p><span style="font-size: 10px">Ive been on trt for 2 years now and had a estrogen crash this fall. From that point on I've been trying to redial my Ai protocol, and at the moment, im at a point where i've decided to ditch my arimidex completely. </span></p><p><span style="font-size: 10px"></span></p><p><span style="font-size: 10px">One of the thing that is worrying me is the fact that I cant seem to shake of the apathy/lethargy ive been experiencing after the crash.</span></p><p><span style="font-size: 10px"></span></p><p><span style="font-size: 10px">I did some reading on this and found few interesting studies that showed how estrogen deprivation lead to apoptosis - cell death - of certain percent of your dopamine producing neurons. </span></p><p></p><p><span style="color: #000000"><span style="font-family: 'Verdana'">The first study was done in ovariectomized female monkeys: </span></span></p><p></p><p><em><strong>Estrogen Deprivation Leads To Death Of Dopamine Cells In The Brain</strong></em><span style="color: #000000"><span style="font-family: 'Verdana'"> </span></span></p><p><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p><p><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span><span style="color: #000000"><span style="font-family: 'Verdana'"> </span></span><a href="https://www.sciencedaily.com/releases/2000/12/001204072446.htm" target="_blank">https://www.sciencedaily.com/releases/2000/12/001204072446.htm</a></p><p></p><p><span style="color: #000000"><span style="font-family: 'Verdana'">"Without estrogen, more than 30 percent of all the dopamine neurons disappeared in a major area of the brain that produces the neurotransmitter, dopamine, " </span></span></p><p></p><p><span style="color: #000000"><span style="font-family: 'Verdana'">"<strong>After both 10 and 30 days of estrogen deprivation, apparently 30 percent of the total number of substantia nigra dopamine cells are lost</strong>," Redmond said. "Furthermore, the density calculations showed that brief estrogen replacement restores the density of the total number of neurons in that area of the brain 10 days after the ovaries have been removed, but not 30 days later."</span></span></p><p></p><p><span style="color: #000000"><span style="font-family: 'Verdana'">This second study was done in male rat's whoms aromatise enxyme was "shut off" </span></span></p><p></p><p><strong></strong></p><p><strong><em>Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice</em></strong></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/15555924" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/15555924</a></p><p></p><p><span style="color: #000000"><span style="font-family: 'Verdana'">"Previously, we have reported that no such changes were observed in the hypothalamus of female ArKO mice. Thus, <strong>we have provided direct evidence that estrogen is required to maintain the survival and functional integrity of dopaminergic neurons in the MPO and Arc of male, but not female mice.</strong>"</span></span></p><p></p><p></p><p>Now of course we should take these animal studies with a grain of salt. I think that if these result applied directly to human males, we would be seeing a lot more men - in different forum's - complaining about low dopamine symptoms despite normal E2 levels. That said these findings made me more cautious on using aromatize inhibitors.</p></blockquote><p></p>
[QUOTE="simeoni, post: 55816, member: 14463"] [SIZE=2]Ive been on trt for 2 years now and had a estrogen crash this fall. From that point on I've been trying to redial my Ai protocol, and at the moment, im at a point where i've decided to ditch my arimidex completely. One of the thing that is worrying me is the fact that I cant seem to shake of the apathy/lethargy ive been experiencing after the crash. I did some reading on this and found few interesting studies that showed how estrogen deprivation lead to apoptosis - cell death - of certain percent of your dopamine producing neurons. [/SIZE] [COLOR=#000000][FONT=Verdana]The first study was done in ovariectomized female monkeys: [/FONT][/COLOR] [I][B]Estrogen Deprivation Leads To Death Of Dopamine Cells In The Brain[/B][/I][COLOR=#000000][FONT=Verdana] [/FONT][/COLOR][COLOR=#000000][FONT=Verdana] [/FONT][/COLOR][URL]https://www.sciencedaily.com/releases/2000/12/001204072446.htm[/URL] [COLOR=#000000][FONT=Verdana]"Without estrogen, more than 30 percent of all the dopamine neurons disappeared in a major area of the brain that produces the neurotransmitter, dopamine, " [/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]"[B]After both 10 and 30 days of estrogen deprivation, apparently 30 percent of the total number of substantia nigra dopamine cells are lost[/B]," Redmond said. "Furthermore, the density calculations showed that brief estrogen replacement restores the density of the total number of neurons in that area of the brain 10 days after the ovaries have been removed, but not 30 days later."[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]This second study was done in male rat's whoms aromatise enxyme was "shut off" [/FONT][/COLOR] [B] [I]Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice[/I][/B] [URL]https://www.ncbi.nlm.nih.gov/pubmed/15555924[/URL] [COLOR=#000000][FONT=Verdana]"Previously, we have reported that no such changes were observed in the hypothalamus of female ArKO mice. Thus, [B]we have provided direct evidence that estrogen is required to maintain the survival and functional integrity of dopaminergic neurons in the MPO and Arc of male, but not female mice.[/B]"[/FONT][/COLOR] Now of course we should take these animal studies with a grain of salt. I think that if these result applied directly to human males, we would be seeing a lot more men - in different forum's - complaining about low dopamine symptoms despite normal E2 levels. That said these findings made me more cautious on using aromatize inhibitors. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Estrogen crash causing permanent apathy/lethargy - by destroying your dopamine neurons?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top