Estradiol Sensitive vs Standard Test

Smokin Joe

Active Member
This the first time that I have compared the Sensitive test to the Standard test.
I had been off of TRT for almost 120 days when this was drawn.
Results: Both are Lab Corp drawn at the same time fasting and two different orders.
Standard: 20.7 - Range 7.6-42.6 pg/ml
Sensitive: 14.6 - Range 8.0-35.0 pg/ml

Looking back over past results the Standard test has always measured between 19.0 and 21.0 consistently.
So by the Sensitive Test am I considered a little low at 14.6 even though in the low end of the range...
 
It is 'normal' for lack of a better word for the regular test to show higher E2 than the sensitive test. It does not happen 100% of the time with 100% of guys, but that is the expected result.

Just curious - how do you feel off TRT now that you are 120 days in?
 
ranges on lab results are hardly a gauge of where you should be especially with the Estradiol tests. It's typical to see standard (which is trash for male usage) higher than the sensitive (correct) test. Nearly anyone is going to reply that 14 on a standard test is too low. The requisite how do feel question not withstanding.
I though, maybe the only guy that's ever seen a higher Sensitive test from the same blood draw in the same lab at the same time. Due to the technicians error inputting the tests, I ended up with both of them. Very interesting to see it that way.
 
ERO after much deliberation I have started TRT again with the intension of staying on as long as I can manage any side affects. Started back 5-13-2016.
While I was off T though my latest blood work showed that I was back to normal as far as numbers go but I felt like I was operating in a vacuum and just going through the motions in life. A little grumpy too.
Total T-497, Free-T 6.8, Estradiol 20.6 and DHEA 70.0.
My Free T and DHEA have always been a little on the low side.
I've tried supplementing with DHEA before but it made me feel bad.
I am trying again as I see the importance of it in all of the information on the forum.
Anyway I'm only one week into TRT again and I feel better already.
Don't know if it's a placebo effect of the exogenous T effect but I'll take it.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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