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ExcelFemale
HRT in Women
Estradiol Lowers Vascular Risk in Post-Menopausal Women
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<blockquote data-quote="Nelson Vergel" data-source="post: 37011" data-attributes="member: 3"><p>APRIL 8, 2016</p><p></p><p>Treatment with oral estradiol is linked with lower subclinical atherosclerosis progression when it is started within 6 years after menopause, according to a study involving 643 healthy postmenopausal women.</p><p></p><p>Participants were divided according to time since menopause, and randomly assigned to receive either oral 17&#946;-estradiol or placebo. Investigators measured carotid-artery intima&#8211;media thickness (CIMT) every 6 months. They also assessed coronary atherosclerosis via CT. Among the results after an average of 5 years of follow-up:</p><p></p><p>• In those who were less than 6 years past menopause, average CIMT increased by 0.0044 mm per year in the estradiol group, vs 0.0078 mm per year in the those receiving placebo. </p><p> </p><p>• Those who were 10 or more years past menopause had similar CIMT progression regardless of what group they were in.</p><p></p><p>• CT measures of coronary-artery calcium, total stenosis, and plaque did not differ significantly between those taking drug or placebo in either menopause contingent.</p><p></p><p><strong>Citation: Hodis H, Mack W, Henderson V, et al. Vascular effects of early versus late postmenopausal treatment with estradiol. [Published online ahead of print March 31, 2016]. <em>N Engl J Med. doi:10.1056/NEJMoa1505241.</em></strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 37011, member: 3"] APRIL 8, 2016 Treatment with oral estradiol is linked with lower subclinical atherosclerosis progression when it is started within 6 years after menopause, according to a study involving 643 healthy postmenopausal women. Participants were divided according to time since menopause, and randomly assigned to receive either oral 17β-estradiol or placebo. Investigators measured carotid-artery intima–media thickness (CIMT) every 6 months. They also assessed coronary atherosclerosis via CT. Among the results after an average of 5 years of follow-up: • In those who were less than 6 years past menopause, average CIMT increased by 0.0044 mm per year in the estradiol group, vs 0.0078 mm per year in the those receiving placebo. • Those who were 10 or more years past menopause had similar CIMT progression regardless of what group they were in. • CT measures of coronary-artery calcium, total stenosis, and plaque did not differ significantly between those taking drug or placebo in either menopause contingent. [B]Citation: Hodis H, Mack W, Henderson V, et al. Vascular effects of early versus late postmenopausal treatment with estradiol. [Published online ahead of print March 31, 2016]. [I]N Engl J Med. doi:10.1056/NEJMoa1505241.[/I][/B] [/QUOTE]
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ExcelFemale
HRT in Women
Estradiol Lowers Vascular Risk in Post-Menopausal Women
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