ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Expert Interviews
Estradiol in Men: Interview with Urology Professor Dr Ranjith Ramasamy
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 70731" data-attributes="member: 3"><p>There is not one study that has looked at the effects of estradiol over 35 on men on testosterone replacement with total testosterone over 500 ng/dL.</p><p></p><p>We know 0.3- 0.4 % of testosterone aromatizes to estradiol. We also know that some references seem to indicate that T/E2 ratios of at least 10 are OK for fertility. We can not just choose one upper E2 value for everyone since this value depends on your total T.</p><p></p><p>Old studies had men with total testosterone much under 400 ng/dL. In those studies, max E2 seemed to be 35-40 pg/ml for higher mortality risk. Those studies do not apply to men like us on TRT who may have values exceeding 600 mg/dL.</p><p></p><p>We definitely know that below the lower limit of 10-20 pg/ml of estradiol, bone loss, low libido and fat gain can occur. We just do not have data that proves what the upper value is to minimize heart disease, edema, ED, etc. </p><p></p><p><strong>"Low blood level of estradiol was associated with significant increases in the percentage of body fat (P<0.001), subcutaneous fat area (P<0.001), and intra abdominal fat area (P = 0.002), and relative less improvement in sexual desire (P<0.001) and erectile function (P = 0.022). These findings provide additional evidence of an independent effect of estradiol on these variables."</strong></p><p><strong></strong></p><p><strong></strong>Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men</p><p>N Engl J Med 2013;369:1011-22</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 70731, member: 3"] There is not one study that has looked at the effects of estradiol over 35 on men on testosterone replacement with total testosterone over 500 ng/dL. We know 0.3- 0.4 % of testosterone aromatizes to estradiol. We also know that some references seem to indicate that T/E2 ratios of at least 10 are OK for fertility. We can not just choose one upper E2 value for everyone since this value depends on your total T. Old studies had men with total testosterone much under 400 ng/dL. In those studies, max E2 seemed to be 35-40 pg/ml for higher mortality risk. Those studies do not apply to men like us on TRT who may have values exceeding 600 mg/dL. We definitely know that below the lower limit of 10-20 pg/ml of estradiol, bone loss, low libido and fat gain can occur. We just do not have data that proves what the upper value is to minimize heart disease, edema, ED, etc. [B]"Low blood level of estradiol was associated with significant increases in the percentage of body fat (P<0.001), subcutaneous fat area (P<0.001), and intra abdominal fat area (P = 0.002), and relative less improvement in sexual desire (P<0.001) and erectile function (P = 0.022). These findings provide additional evidence of an independent effect of estradiol on these variables." [/B]Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men N Engl J Med 2013;369:1011-22 [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Expert Interviews
Estradiol in Men: Interview with Urology Professor Dr Ranjith Ramasamy
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top