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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Estradiol bloodwork results and how to interpret ranges sensitive vs. "regular"
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 30697" data-attributes="member: 12687"><p>We use the LC/MS/MS, but the Roche ECLIA is better than nothing (better than not testing at all, in other words). The sensitive test is more expensive. We at Defy and Nelson with Discounted Labs have negotiated a MUCH lower price than is available to other providers on the sensitive E2 test. The biggest deficiency of the RIA (standard test) is that it can cross-react with C-reactive protein. For folks that have an elevated CRP (or simply a CRP that is NOT low), the RIA may indeed overestimate E2 levels quite a bit. If cost is a factor, I would suggest ordering your own labs through Discounted Labs for a reduced price on the sensitive E2. Compare that cost to the cost you currently pay for the standard E2 PLUS a C-reactive protein test (which you should test concurrently with the standard E2 to "calibrate" your results and make sure you are not elevated on CRP). If the cost of the standard E2 + CRP is still significantly less than the price for the sensitive E2 test...then you have a decision to make. I suspect the sensitive E2 test will have a more attractive price point when viewed in that light. Either way, correlating your levels with symptoms is the key. Good luck.</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 30697, member: 12687"] We use the LC/MS/MS, but the Roche ECLIA is better than nothing (better than not testing at all, in other words). The sensitive test is more expensive. We at Defy and Nelson with Discounted Labs have negotiated a MUCH lower price than is available to other providers on the sensitive E2 test. The biggest deficiency of the RIA (standard test) is that it can cross-react with C-reactive protein. For folks that have an elevated CRP (or simply a CRP that is NOT low), the RIA may indeed overestimate E2 levels quite a bit. If cost is a factor, I would suggest ordering your own labs through Discounted Labs for a reduced price on the sensitive E2. Compare that cost to the cost you currently pay for the standard E2 PLUS a C-reactive protein test (which you should test concurrently with the standard E2 to "calibrate" your results and make sure you are not elevated on CRP). If the cost of the standard E2 + CRP is still significantly less than the price for the sensitive E2 test...then you have a decision to make. I suspect the sensitive E2 test will have a more attractive price point when viewed in that light. Either way, correlating your levels with symptoms is the key. Good luck. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Estradiol bloodwork results and how to interpret ranges sensitive vs. "regular"
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