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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Estradiol and Social Anxiety
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<blockquote data-quote="Jim Marlowe" data-source="post: 267087" data-attributes="member: 45320"><p><h4>[USER=42634]drpub2112[/USER] This is a great post. I think you are spot on. Increased serotonin is central to many health problems. But with a slow MAO-A gene, exogenous T effectively results in an imbalance of serotonin to dopamine. Both go up on T administration, but serotonin remains high in those with the slow MAO-A gene because the enzyme does not clear it as fast. Obviously that is a gross oversimplification of a complex process involving 5-HT, but essentially that is what happens. The only quibble I would have is men only have one copy of the gene at RS6323 (R297R) because it is inherited on the X chromosome. So if you are male, then you are just +, not +/+. That would be the T allele if you are slow MAO-A. G is the "fast" version. And the literature suggests women have different expression from the alleles than men. I suspect there will be much more insight into these issues with the advent of affordable whole-genome sequencing. </h4></blockquote><p></p>
[QUOTE="Jim Marlowe, post: 267087, member: 45320"] [HEADING=3][USER=42634]drpub2112[/USER] This is a great post. I think you are spot on. Increased serotonin is central to many health problems. But with a slow MAO-A gene, exogenous T effectively results in an imbalance of serotonin to dopamine. Both go up on T administration, but serotonin remains high in those with the slow MAO-A gene because the enzyme does not clear it as fast. Obviously that is a gross oversimplification of a complex process involving 5-HT, but essentially that is what happens. The only quibble I would have is men only have one copy of the gene at RS6323 (R297R) because it is inherited on the X chromosome. So if you are male, then you are just +, not +/+. That would be the T allele if you are slow MAO-A. G is the "fast" version. And the literature suggests women have different expression from the alleles than men. I suspect there will be much more insight into these issues with the advent of affordable whole-genome sequencing. [/HEADING] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Estradiol and Social Anxiety
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