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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Estradiol and Social Anxiety
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<blockquote data-quote="drpub2112" data-source="post: 229635" data-attributes="member: 42634"><p>If having more norepinephrine and serotonin in your brain reduces your anxiety and allows you to think more camly and clearly then yes, of course. But, if having more neurotransmitters induces anxiety, anger, fear, and cognitive dissonance, then no, it's bad.</p><p></p><p>It all comes down to your personal genetics. Some people do great on MOA inhibiting substances. There are alot of different genes that make up your personality traits and overall resilience to stress. They interact in complex ways but MAO-A is the major determinant of CSF serotonin and norepinephrine levels. Androgens lower MAO-A specifically by the conversion of T to E. In the following study, T also increased MAO-B.</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520442/[/URL]</p><p></p><p>The internet frequently promotes the notion that emotional disturbances are primarily caused by low neurotransmitter levels. So the obvious thing to deduce is that more serotonin is better. For many people (maybe a majority? idk) this works out OK, because they are either MAO-A normals or high producers. But if you are a low MAO-A producer, things that further supress MAO-A will make you feel much worse, very quickly.</p><p></p><p>The only point I'm trying to make with my post is that MAO-A genes (among others) are probably what dictates a persons tolerance for elevated E2 on TRT or a high E2:T ratio before TRT. People with naturally high OR low MAO-A production likely have a history of mental health issues because of it's direct effect on neurotransmission. E2 makes me batshit crazy, but I've seen guys on youtube with E2 of 60pg/DL saying they feel fine. Everyone is different.</p></blockquote><p></p>
[QUOTE="drpub2112, post: 229635, member: 42634"] If having more norepinephrine and serotonin in your brain reduces your anxiety and allows you to think more camly and clearly then yes, of course. But, if having more neurotransmitters induces anxiety, anger, fear, and cognitive dissonance, then no, it's bad. It all comes down to your personal genetics. Some people do great on MOA inhibiting substances. There are alot of different genes that make up your personality traits and overall resilience to stress. They interact in complex ways but MAO-A is the major determinant of CSF serotonin and norepinephrine levels. Androgens lower MAO-A specifically by the conversion of T to E. In the following study, T also increased MAO-B. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520442/[/URL] The internet frequently promotes the notion that emotional disturbances are primarily caused by low neurotransmitter levels. So the obvious thing to deduce is that more serotonin is better. For many people (maybe a majority? idk) this works out OK, because they are either MAO-A normals or high producers. But if you are a low MAO-A producer, things that further supress MAO-A will make you feel much worse, very quickly. The only point I'm trying to make with my post is that MAO-A genes (among others) are probably what dictates a persons tolerance for elevated E2 on TRT or a high E2:T ratio before TRT. People with naturally high OR low MAO-A production likely have a history of mental health issues because of it's direct effect on neurotransmission. E2 makes me batshit crazy, but I've seen guys on youtube with E2 of 60pg/DL saying they feel fine. Everyone is different. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Estradiol and Social Anxiety
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