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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Estradiol and Social Anxiety
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<blockquote data-quote="drpub2112" data-source="post: 229598" data-attributes="member: 42634"><p>The only way to know for sure is to see how you feel at different E2 levels. Everyones individual genetics will dictate how they feel. There's just too much going on to predict how E2 modulation will effect you.</p><p></p><p>For example, I have a low producing variant of the MAO-A gene which regulates the rate that many neurotransmitters and hormones are broken down, serotonin and dopamine among the most important. MAO-A is a major correlate with lots of mental heath traits.</p><p></p><p>Estrogen levels have an inverse relationship to MAO-A levels, so high E2 from TRT drops my MAO levels even lower than normal and exacerbates all my problems with negative emotions. Whenever I get triggered and get feelings of anxiety, anger, or fear, I can't easily come back to baseline because of natually low levels of MAO-A, E2 spikes make it worse.</p><p></p><p>But if someone else has normal or high producing MAO-A gene variants, the effects of higher-than-average E2 may not be noticable at all. It might even make them feel better. Hormones, neurotransmitters, and genes are so intimately interwoven that there is no way to tell how manipulating only 1 or 2 will effect your individual mental state. In my case, the natural lowering of T with the rise of E that comes with aging makes all of the existing mental health issues I had in my youth progressively worse. </p><p></p><p>So, the only blanket statement that can really be made about it is that both low and high E2 levels can produce negative symptoms, to widly varying degrees among men. High anxiety states can definately be exacerbated by out-of-range estrogen levels.</p></blockquote><p></p>
[QUOTE="drpub2112, post: 229598, member: 42634"] The only way to know for sure is to see how you feel at different E2 levels. Everyones individual genetics will dictate how they feel. There's just too much going on to predict how E2 modulation will effect you. For example, I have a low producing variant of the MAO-A gene which regulates the rate that many neurotransmitters and hormones are broken down, serotonin and dopamine among the most important. MAO-A is a major correlate with lots of mental heath traits. Estrogen levels have an inverse relationship to MAO-A levels, so high E2 from TRT drops my MAO levels even lower than normal and exacerbates all my problems with negative emotions. Whenever I get triggered and get feelings of anxiety, anger, or fear, I can't easily come back to baseline because of natually low levels of MAO-A, E2 spikes make it worse. But if someone else has normal or high producing MAO-A gene variants, the effects of higher-than-average E2 may not be noticable at all. It might even make them feel better. Hormones, neurotransmitters, and genes are so intimately interwoven that there is no way to tell how manipulating only 1 or 2 will effect your individual mental state. In my case, the natural lowering of T with the rise of E that comes with aging makes all of the existing mental health issues I had in my youth progressively worse. So, the only blanket statement that can really be made about it is that both low and high E2 levels can produce negative symptoms, to widly varying degrees among men. High anxiety states can definately be exacerbated by out-of-range estrogen levels. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Estradiol and Social Anxiety
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