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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Erectile Dysfunction Pharmacotherapy
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<blockquote data-quote="madman" data-source="post: 245590" data-attributes="member: 13851"><p><em><strong>*The main advantage of PDE5is results in the improvement of sexual performance but not libido</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*H<em><strong>uman penile ED is controlled by five factors, including local biological basis, systemic neuroendocrine regulation, behavioristics, personality cognition, and social, and environmental factors. Lesions that occur in any of those levels can cause ED</strong></em></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Vascular endothelial cell plays an important role in the regulation of coagulation and inflammation in the human body</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*NO is a key neurotransmitter that maintains the relaxation of the smooth muscle of the corpus cavernosum</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*PDE5 inhibitors are the breakthrough therapy in the treatment of ED. The PDE5 inhibitor selectively inhibits PDE5 and increases the amount of cGMP available for smooth-muscle relaxation, inducing vasodilatation, and increasing corporal blood flow and erection</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*They are not the initiators of erections and need to be given sexual stimulation</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Some patients, especially those with diabetes mellitus complicated with ED or radical prostatectomy, had a poor response to these drugs. <u>Severe endothelial dysfunction and cavernous nerve injury are the main causes</u>.</strong> <strong>Because the action of PDE5 inhibitors was dependent on endogenous NO formation, if endogenous bioavailable NO is insufficient due to severe endothelial dysfunction or nerve damage, PDE5 inhibitors may not be sufficient to raise the level of cGMP above the necessary threshold. In addition, PDE5 inhibitors cannot reverse the potential vascular or neurological dysfunction associated with ED</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 245590, member: 13851"] [I][B]*The main advantage of PDE5is results in the improvement of sexual performance but not libido *H[I][B]uman penile ED is controlled by five factors, including local biological basis, systemic neuroendocrine regulation, behavioristics, personality cognition, and social, and environmental factors. Lesions that occur in any of those levels can cause ED[/B][/I] *Vascular endothelial cell plays an important role in the regulation of coagulation and inflammation in the human body *NO is a key neurotransmitter that maintains the relaxation of the smooth muscle of the corpus cavernosum *PDE5 inhibitors are the breakthrough therapy in the treatment of ED. The PDE5 inhibitor selectively inhibits PDE5 and increases the amount of cGMP available for smooth-muscle relaxation, inducing vasodilatation, and increasing corporal blood flow and erection *They are not the initiators of erections and need to be given sexual stimulation *Some patients, especially those with diabetes mellitus complicated with ED or radical prostatectomy, had a poor response to these drugs. [U]Severe endothelial dysfunction and cavernous nerve injury are the main causes[/U].[/B] [B]Because the action of PDE5 inhibitors was dependent on endogenous NO formation, if endogenous bioavailable NO is insufficient due to severe endothelial dysfunction or nerve damage, PDE5 inhibitors may not be sufficient to raise the level of cGMP above the necessary threshold. In addition, PDE5 inhibitors cannot reverse the potential vascular or neurological dysfunction associated with ED[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Erectile Dysfunction Pharmacotherapy
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