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Wanted to post an update on this.  Appreciate the help from everyone hoping my results can be of help to others.  Also have a few follow up ?s..


So gradually i have worked my way up to 100ius of HCG EOD while lowering my dose from 126mg/wk to 105mg/wk.  FunkOdyssey was spot on, i feel better in almost every measurable category since adding the HCG (although my E2 did not go up, more on this later..).  Only negative thing i was noticing was familiar feeling like my T was too high.  Also put on a few unexplainable lbs of muscle which seems to happen to me when TT gets at/over 1200ish.


Anyway after few titrations then additional 6 weeks took bloods and results are shocking..


TT ballooned despite the 17% dose reduction?  E2 exactly the same while DHT doubled??  Now my TT to E2 ratios is over 50??

Any thoughts on this?


Any theories as to why I would be a hyper responder to HCG?  Anyone else respond similarly to HCG and use it as a base with no T or a low dose (50mg or less/wk) as a supplemental?


By my math - my total T level was 956 on 126mg without HCG.  Reducing dose by 17% should have a pretty linear reduction in total test to 793.  With TT at 1246 this would suggest that 452pts came from just 350iu/wk of HCG.  If I doubled my HCG dose and got rid of the test completely, do you guys think 452 would double to 900 and I could maintain these levels on HCG mono??


Luckily fertility is back on my radar and i have a great opportunity to continue to swap exogenous T for HCG and see what happens.  Curious for some feedback and happy to share labs and experience as I further experiment.


PS here are labs


Test

Reference Range

10/3/2024


8/1/2024




5/31/2024





Protocol--->

105mg/wk (EOD) Test E. + 100iu HCG EOD

126mg/wk (EOD) test E. NO hcg NO AI

140mg/wk (EOD) Test E. + HCG 50iu EOD NO AI











Hormone









SHBG

10-50nmol/L

38


27




26



Testosterone, Total, MS

250-1100ng/dL

1246


956




1255



Testosterone, Free (E.D.)

35-155pg/mL

216.8


190.2




291.2



DHT

12-65ng/dL

75


48





Estradiol, Ultrasensitive

<=29pg/mL

24


24




30



DHEA Sulfate

93-415mcg/dL

102


111





Progesterone

<1.4ng/mL

<0.5

<0.5



Pregnenolone, LC/MS

22-237ng/dL

22


32





Prolactin

2-18ng/mL

6.9


6.3





Total T to e2 Ratio




51.92




39.83




41.83



Vermeulen Free T calc



29.05ng/dl

25.27ng/dl

35.82ng/dl

Iron / RBC






2.51%




2.39%



Ferritin

38-180ng/mL

115


107




81



Iron, Total

50-180

130


89




140



Iron Binding Capacity

250-425mcg/dL

325


354




348



% Saturation

20-48%

40


25




40



Hemoglobin

13.2-17.1g/dL

16.1


16.2




16.8



Hematocrit

38.5-50%

47.8


49.3




50













Thyroid









TSH

0.4-4.5mlU/L

1.94


2.54





T4

4.9-10.5mcg/dL

6.8


8





T4, Free

0.8-1.8ng/dL

1.3


1.6





T3, Free

2.3-4.2pg/ml

3.1


4





T3, Total

76-181ng/dL

75


100















Other









IGF-1

53-331ng/mL

147


220





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