ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Endogenous circulating testosterone and sex hormone-binding globulin levels and measures of myocardial structure and function: the Framingham Heart
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 138552" data-attributes="member: 13851"><p><strong>Endogenous circulating testosterone and sex hormone-binding globulin levels and measures of myocardial structure and function: the Framingham Heart Study </strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">K. M. Pencina , T. G. Travison, S. Bhasin, Z. Li, N. Nigam, W. J. Manning, R. S. Vasan, U. Hoffmann, C. J. O’Donnell and S. Basaria </span></strong></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>ABSTRACT</strong></p><p><strong><span style="color: rgb(184, 49, 47)">Background:</span></strong> The relation between endogenous testosterone concentrations and myocardial mass and function remains incompletely understood.</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Objectives: </span></strong>To determine the cross-sectional association between endogenous hormone levels with cardiac magnetic resonance measures of myocardial mass, structure, and function in community-dwelling men across a wide age range. Methods: A total of 720 men from the Framingham Heart Study Offspring Cohort (age range 37–82, mean = 59.6 years) who underwent cardiac magnetic resonance imaging and had hormone levels measured. Total testosterone (measured using liquid chromatography-tandem mass spectrometry), sex hormone-binding globulin (measured using an immunofluorometric assay), and calculated free testosterone levels were assessed in male participants of the Framingham Heart Study Offspring Cohort at examination 7. Cardiac magnetic resonance imaging was performed between examinations 7 and 8 (2002–2006).</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Results:</span></strong> Age-adjusted linear regression models showed statistically significant association between total testosterone levels and left ventricular mass (p = 0.009), left ventricular mass index (p = 0.006), cardiac output (p = 0.001), and main pulmonary artery diameter (p = 0.008); the association between total testosterone and these cardiac magnetic resonance measures was weak and was not significant after adjustment for established risk factors—age, body mass index, diabetes, and hypertension. Furthermore, calculated free testosterone level was not significantly associated with any measure of myocardial mass or function. Sex hormone-binding globulin level was significantly associated with left ventricular mass (p = 0.002), left ventricular mass index (p = 0.004), cardiac output (p = 0.003), left ventricular ejection fraction (p = 0.039), and main pulmonary artery diameter (p = 0.042) in age-adjusted models; these associations were also rendered non-significant after adjusting for cardiovascular risk factors.</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Conclusions: </span></strong>Neither testosterone nor sex hormone-binding globulin levels in men are associated significantly with myocardial mass and function independent of established cardiovascular risk factors.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>CONCLUSION </strong></p><p>In summary, <span style="color: rgb(184, 49, 47)"><strong>our analyses do not reveal a significant and clinically meaningful association of testosterone levels with measures of myocardial mass or function. </strong></span>Further prospective studies are needed to elucidate the role of androgen in the regulation of myocardial mass and function in men, if any. <strong>However, the results of our analyses do not support an important role for circulating testosterone levels in regulation of myocardial mass and function in adult men. </strong></p></blockquote><p></p>
[QUOTE="madman, post: 138552, member: 13851"] [B]Endogenous circulating testosterone and sex hormone-binding globulin levels and measures of myocardial structure and function: the Framingham Heart Study [/B] [B][COLOR=rgb(184, 49, 47)]K. M. Pencina , T. G. Travison, S. Bhasin, Z. Li, N. Nigam, W. J. Manning, R. S. Vasan, U. Hoffmann, C. J. O’Donnell and S. Basaria [/COLOR][/B] [B]ABSTRACT [COLOR=rgb(184, 49, 47)]Background:[/COLOR][/B] The relation between endogenous testosterone concentrations and myocardial mass and function remains incompletely understood. [B][COLOR=rgb(184, 49, 47)]Objectives: [/COLOR][/B]To determine the cross-sectional association between endogenous hormone levels with cardiac magnetic resonance measures of myocardial mass, structure, and function in community-dwelling men across a wide age range. Methods: A total of 720 men from the Framingham Heart Study Offspring Cohort (age range 37–82, mean = 59.6 years) who underwent cardiac magnetic resonance imaging and had hormone levels measured. Total testosterone (measured using liquid chromatography-tandem mass spectrometry), sex hormone-binding globulin (measured using an immunofluorometric assay), and calculated free testosterone levels were assessed in male participants of the Framingham Heart Study Offspring Cohort at examination 7. Cardiac magnetic resonance imaging was performed between examinations 7 and 8 (2002–2006). [B][COLOR=rgb(184, 49, 47)]Results:[/COLOR][/B] Age-adjusted linear regression models showed statistically significant association between total testosterone levels and left ventricular mass (p = 0.009), left ventricular mass index (p = 0.006), cardiac output (p = 0.001), and main pulmonary artery diameter (p = 0.008); the association between total testosterone and these cardiac magnetic resonance measures was weak and was not significant after adjustment for established risk factors—age, body mass index, diabetes, and hypertension. Furthermore, calculated free testosterone level was not significantly associated with any measure of myocardial mass or function. Sex hormone-binding globulin level was significantly associated with left ventricular mass (p = 0.002), left ventricular mass index (p = 0.004), cardiac output (p = 0.003), left ventricular ejection fraction (p = 0.039), and main pulmonary artery diameter (p = 0.042) in age-adjusted models; these associations were also rendered non-significant after adjusting for cardiovascular risk factors. [B][COLOR=rgb(184, 49, 47)]Conclusions: [/COLOR][/B]Neither testosterone nor sex hormone-binding globulin levels in men are associated significantly with myocardial mass and function independent of established cardiovascular risk factors. [B]CONCLUSION [/B] In summary, [COLOR=rgb(184, 49, 47)][B]our analyses do not reveal a significant and clinically meaningful association of testosterone levels with measures of myocardial mass or function. [/B][/COLOR]Further prospective studies are needed to elucidate the role of androgen in the regulation of myocardial mass and function in men, if any. [B]However, the results of our analyses do not support an important role for circulating testosterone levels in regulation of myocardial mass and function in adult men. [/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Endogenous circulating testosterone and sex hormone-binding globulin levels and measures of myocardial structure and function: the Framingham Heart
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top