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It's common for guys to experience either a slight reduction or no change in libido when taking enclomiphene. Enclomiphene antagonizes the estrogen receptors in the hypothalamus, which can negatively impact libido. The zuclomiphene isomer in clomid, on the other hand, is an estrogen receptor agonist.  If the dose of clomd is low enough, it may be possible to achieve enough estrogenic activity in the brain to offset enclomiphene's antagonist effect without experiencing the well known emotional side effects of clomid.


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