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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Elevated TSH on TRT/HCG
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 34606" data-attributes="member: 12687"><p>Good stuff, FrankUnderwood, and indeed hCG shares a close structural similarity to endogenous TSH. A few points however:</p><p></p><p>- hCG can have a modest stimulatory effect on the thyroid (via its structural similarity to TSH), but this is typically at HIGHER serum hCG levels often achieved with VERY HIGH dosing (female fertility treatment for example) or more commonly during pregnancy (where serum hCG concentrations can reach into the tens of thousands mIU/mL ---for comparison, with my recent case studies of serum hCG levels after hCG injections, we found that maximal serum hCG concentration after even a 500iu injection was only ~3mIU/mL). </p><p></p><p>- stimulation of the thyroid (via pseudo-"mimicking" TSH) would actually LOWER endogenous TSH levels (as seen during pregnancy). OP's TSH was ELEVATED.</p><p></p><p>Good questions nonetheless and certainly an interesting case!</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 34606, member: 12687"] Good stuff, FrankUnderwood, and indeed hCG shares a close structural similarity to endogenous TSH. A few points however: - hCG can have a modest stimulatory effect on the thyroid (via its structural similarity to TSH), but this is typically at HIGHER serum hCG levels often achieved with VERY HIGH dosing (female fertility treatment for example) or more commonly during pregnancy (where serum hCG concentrations can reach into the tens of thousands mIU/mL ---for comparison, with my recent case studies of serum hCG levels after hCG injections, we found that maximal serum hCG concentration after even a 500iu injection was only ~3mIU/mL). - stimulation of the thyroid (via pseudo-"mimicking" TSH) would actually LOWER endogenous TSH levels (as seen during pregnancy). OP's TSH was ELEVATED. Good questions nonetheless and certainly an interesting case! [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Elevated TSH on TRT/HCG
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