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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Elevated LH/Normal T Levels in Older Men - Natural History, Risk, Clinical Features
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<blockquote data-quote="CoastWatcher" data-source="post: 88529" data-attributes="member: 2624"><p>Elevated LH with normal testosterone (T) suggests <em>compensated</em> dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the development of high LH (HLH, LH>9.4 U/L) in ageing men with normal T (T&#8805;10.5 nmol/L, 274 ng/dl). </p><p></p><p> </p><ul> <li data-xf-list-type="ul">A 4.3 year prospective observational study of 3,369 community-dwelling European men aged 40-79 years.</li> <li data-xf-list-type="ul">Participants were classified as: incident (i) HLH (n=101, 5.2%); persistent (p) HLH (n=128, 6.6%); reverted (r) HLH (n=46, 2.4%); or persistent normal LH (pNLH, n=1667, 85.8%).</li> <li data-xf-list-type="ul">Potential predictors and changes in clinical features associated with iHLH and rHLH were analysed using regression models.</li> </ul><p><strong></strong></p><p><strong>RESULTS: </strong></p><p><strong></strong></p><ul> <li data-xf-list-type="ul">Age greater than 70 years, diabetes, chronic pain pre-degree education, and low physical activity predicted development of HLH. <br /> </li> <li data-xf-list-type="ul">Younger age, 40-49 years, and non-smoking predicted recovery from HLH. <br /> </li> <li data-xf-list-type="ul">Men with iHLH developed erectile dysfunction, poor health, cardiovascular disease (CVD) and cancer more frequently than pNLH men. <br /> </li> <li data-xf-list-type="ul">In pHLH men, co-morbidities, including CVD, developed more frequently, and cognitive and physical function deteriorated more, than in pNLH men. <br /> </li> <li data-xf-list-type="ul">Men with HLH developed primary hypogonadism more frequently than NLH men. Men with rHLH experienced a small rise in BMI.</li> </ul><p></p><p>Elevation of LH with normal T is predicted by multiple factors, reverts frequently and is not associated with unequivocal evidence of androgen deficiency. High LH is a biomarker for deteriorating health in aged men who tend to develop primary hypogonadism. </p><p></p><p>"Elevated Luteinising Hormone despite Normal Testosterone Levels in older Men - Natural History, Risk Factors, and Clinical Features," <em>Clinical Endocrinology, </em>2017 Novenmber 27, <a href="https://www.ncbi.nlm.nih.gov/pubmed/29178359/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29178359/</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 88529, member: 2624"] Elevated LH with normal testosterone (T) suggests [I]compensated[/I] dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the development of high LH (HLH, LH>9.4 U/L) in ageing men with normal T (T≥10.5 nmol/L, 274 ng/dl). [LIST] [*]A 4.3 year prospective observational study of 3,369 community-dwelling European men aged 40-79 years. [*]Participants were classified as: incident (i) HLH (n=101, 5.2%); persistent (p) HLH (n=128, 6.6%); reverted (r) HLH (n=46, 2.4%); or persistent normal LH (pNLH, n=1667, 85.8%). [*]Potential predictors and changes in clinical features associated with iHLH and rHLH were analysed using regression models. [/LIST] [B] RESULTS: [/B] [LIST] [*]Age greater than 70 years, diabetes, chronic pain pre-degree education, and low physical activity predicted development of HLH. [*]Younger age, 40-49 years, and non-smoking predicted recovery from HLH. [*]Men with iHLH developed erectile dysfunction, poor health, cardiovascular disease (CVD) and cancer more frequently than pNLH men. [*]In pHLH men, co-morbidities, including CVD, developed more frequently, and cognitive and physical function deteriorated more, than in pNLH men. [*]Men with HLH developed primary hypogonadism more frequently than NLH men. Men with rHLH experienced a small rise in BMI. [/LIST] Elevation of LH with normal T is predicted by multiple factors, reverts frequently and is not associated with unequivocal evidence of androgen deficiency. High LH is a biomarker for deteriorating health in aged men who tend to develop primary hypogonadism. "Elevated Luteinising Hormone despite Normal Testosterone Levels in older Men - Natural History, Risk Factors, and Clinical Features," [I]Clinical Endocrinology, [/I]2017 Novenmber 27, [URL]https://www.ncbi.nlm.nih.gov/pubmed/29178359/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Elevated LH/Normal T Levels in Older Men - Natural History, Risk, Clinical Features
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