ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Elevated DHT levels...prostate...@Dr Justin Saya MD
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="JimBob" data-source="post: 153103" data-attributes="member: 19076"><p><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357" target="_blank">Pharmacokinetics of testosterone cream applied to scrotal skin</a></p><p>"Disproportionate increases in serum DHT are reported after administration of all transdermal testosterone products with the higher DHT/T ratio attributable to the strong expression of 5‐alpha reductase in skin structures which foster the conversion of testosterone to DHT during transdermal passage. Furthermore androgens induce greater expression of the 5α reductase enzyme whereby administration of an androgen directly onto the skin creates a feed‐forward (positive feedback) mechanism (Russell & Wilson, <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0042" target="_blank">1994</a>; McNamara <em>et al</em>., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0033" target="_blank">2013</a>). Analogous disproportionate increases in serum DHT (creating a higher DHT/T ratio) are also reported after oral testosterone undecanoate (Schnabel <em>et al</em>., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0044" target="_blank">2007</a>; Yin <em>et al</em>., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0053" target="_blank">2012</a>). <strong><u>The clinical significance of such increased DHT/T ratio, common to all non‐parenteral routes of testosterone administration, is doubtful as studies maintained circulating DHT levels of 10 times the physiological concentrations for up to 2 years without increasing prostate size or growth or any adverse sequelae (Idan <em>et al</em>., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0021" target="_blank">2010</a>) nor do exogenous androgens increase intraprostatic DHT (Marks <em>et al</em>., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0031" target="_blank">2006</a>; Page <em>et al</em>., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0039" target="_blank">2011</a>; Mostaghel <em>et al</em>., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0037" target="_blank">2012</a>; Thirumalai <em>et al</em>., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0047" target="_blank">2016</a>). </u></strong></p></blockquote><p></p>
[QUOTE="JimBob, post: 153103, member: 19076"] [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357']Pharmacokinetics of testosterone cream applied to scrotal skin[/URL] "Disproportionate increases in serum DHT are reported after administration of all transdermal testosterone products with the higher DHT/T ratio attributable to the strong expression of 5‐alpha reductase in skin structures which foster the conversion of testosterone to DHT during transdermal passage. Furthermore androgens induce greater expression of the 5α reductase enzyme whereby administration of an androgen directly onto the skin creates a feed‐forward (positive feedback) mechanism (Russell & Wilson, [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0042']1994[/URL]; McNamara [I]et al[/I]., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0033']2013[/URL]). Analogous disproportionate increases in serum DHT (creating a higher DHT/T ratio) are also reported after oral testosterone undecanoate (Schnabel [I]et al[/I]., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0044']2007[/URL]; Yin [I]et al[/I]., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0053']2012[/URL]). [B][U]The clinical significance of such increased DHT/T ratio, common to all non‐parenteral routes of testosterone administration, is doubtful as studies maintained circulating DHT levels of 10 times the physiological concentrations for up to 2 years without increasing prostate size or growth or any adverse sequelae (Idan [I]et al[/I]., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0021']2010[/URL]) nor do exogenous androgens increase intraprostatic DHT (Marks [I]et al[/I]., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0031']2006[/URL]; Page [I]et al[/I]., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0039']2011[/URL]; Mostaghel [I]et al[/I]., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0037']2012[/URL]; Thirumalai [I]et al[/I]., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12357#andr12357-bib-0047']2016[/URL]). [/U][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Elevated DHT levels...prostate...@Dr Justin Saya MD
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top