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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating BPH and androgen deficiency
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<blockquote data-quote="madman" data-source="post: 181448" data-attributes="member: 13851"><p><strong>A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Abstract </strong></p><p><strong></strong></p><p><strong>Background:</strong> <span style="color: rgb(44, 130, 201)"><em>The present clinical trial was conducted to evaluate the efficacy and tolerability of a standardized saw palmetto oil containing 3% β-sitosterol in the treatment of benign prostate hyperplasia (BPH) and androgen deficiency.</em></span></p><p></p><p><strong>Methods:</strong> Subjects aged 40–65 years with symptomatic BPH were randomized to 12-week double-blind treatment with 500 mg doses of β-sitosterol enriched saw palmetto oil, conventional saw palmetto oil and placebo orally in the form of capsules (n = 33 in each group). BPH severity was determined using the International Prostate Symptom Score (IPSS), uroflowmetry, serum measurement of prostate specific antigen (PSA), testosterone and 5α-reductase. During the trial, the androgen deficiency was evaluated using Aging Male Symptoms (AMS) scale, the Androgen Deficiency in the Aging Male (ADAM) questionnaire, serum levels of free testosterone.</p><p></p><p><strong>Results:</strong> <span style="color: rgb(0, 0, 0)"><em>Subjects treated with β-sitosterol enriched saw palmetto oil showed significant decrease in IPSS, AMS and ADAM scores along with reduced postvoiding residual volume (p < 0.001), PSA (p < 0.01) and 5α-reductase from baseline to end of 12-week treatment as compared to placebo. There was also a significant increment in the maximum and average urine flow rate (p < 0.001), and serum free testosterone level of subjects treated with enriched saw palmetto oil as compared to placebo. </em></span></p><p><span style="color: rgb(0, 0, 0)"></span></p><p><span style="color: rgb(0, 0, 0)"><strong>Conclusion:</strong> </span><span style="color: rgb(41, 105, 176)"><strong><em>This study demonstrates the efficacy of β-sitosterol enriched saw palmetto oil superior to conventional oil thus extending the scope of effective BPH and androgen deficiency treatment with improved quality of life through the intake of functional ingredients.</em></strong></span></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Conclusion</strong></p><p></p><p><em><strong><span style="color: rgb(184, 49, 47)">The present study provides first ever clinical evidence on the improved efficacy of saw palmetto oil due to the enriched content of β-sitosterol. </span></strong><span style="color: rgb(184, 49, 47)">This comparative study clearly recommends the use of a phytosterol-enriched saw palmetto oil as a functional ingredient in dietary supplements for effective management of symptomatic BPH. </span></em></p></blockquote><p></p>
[QUOTE="madman, post: 181448, member: 13851"] [B]A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency Abstract Background:[/B] [COLOR=rgb(44, 130, 201)][I]The present clinical trial was conducted to evaluate the efficacy and tolerability of a standardized saw palmetto oil containing 3% β-sitosterol in the treatment of benign prostate hyperplasia (BPH) and androgen deficiency.[/I][/COLOR] [B]Methods:[/B] Subjects aged 40–65 years with symptomatic BPH were randomized to 12-week double-blind treatment with 500 mg doses of β-sitosterol enriched saw palmetto oil, conventional saw palmetto oil and placebo orally in the form of capsules (n = 33 in each group). BPH severity was determined using the International Prostate Symptom Score (IPSS), uroflowmetry, serum measurement of prostate specific antigen (PSA), testosterone and 5α-reductase. During the trial, the androgen deficiency was evaluated using Aging Male Symptoms (AMS) scale, the Androgen Deficiency in the Aging Male (ADAM) questionnaire, serum levels of free testosterone. [B]Results:[/B] [COLOR=rgb(0, 0, 0)][I]Subjects treated with β-sitosterol enriched saw palmetto oil showed significant decrease in IPSS, AMS and ADAM scores along with reduced postvoiding residual volume (p < 0.001), PSA (p < 0.01) and 5α-reductase from baseline to end of 12-week treatment as compared to placebo. There was also a significant increment in the maximum and average urine flow rate (p < 0.001), and serum free testosterone level of subjects treated with enriched saw palmetto oil as compared to placebo. [/I] [B]Conclusion:[/B] [/COLOR][COLOR=rgb(41, 105, 176)][B][I]This study demonstrates the efficacy of β-sitosterol enriched saw palmetto oil superior to conventional oil thus extending the scope of effective BPH and androgen deficiency treatment with improved quality of life through the intake of functional ingredients.[/I][/B][/COLOR] [B]Conclusion[/B] [I][B][COLOR=rgb(184, 49, 47)]The present study provides first ever clinical evidence on the improved efficacy of saw palmetto oil due to the enriched content of β-sitosterol. [/COLOR][/B][COLOR=rgb(184, 49, 47)]This comparative study clearly recommends the use of a phytosterol-enriched saw palmetto oil as a functional ingredient in dietary supplements for effective management of symptomatic BPH. [/COLOR][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating BPH and androgen deficiency
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