ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
ExcelFemale
HRT in Women
Efficacy of oral estrogen plus testosterone gel to improve sexual function in postmenopausal women
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 140257" data-attributes="member: 13851"><p><strong>Efficacy of oral estrogen plus testosterone gel to improve sexual function in postmenopausal women </strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">S. Chaikittisilpa, K. Soimongkol & U. Jaisamrarn </span></strong></p><p></p><p></p><p></p><p></p><p></p><p><strong>ABSTRACT </strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Objective: </span></strong>This study aimed to study the efficacy and safety of estrogen plus low-dose testosterone gel in improving sexual function in postmenopausal women. </p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Methods:</span></strong> A double-blind, randomized, active-controlled trial was conducted. Seventy postmenopausal women with low sexual function were randomized into two groups. They received weekly 50 mg of transdermal testosterone plus daily oral 1 mg estradiol valerate or only estrogen for 8 weeks. The Female Sexual Function Index (FSFI) score, hematocrit, liver enzymes, lipid profiles, total testosterone, free and bioavailable testosterone, free androgen index, sex hormone binding globulin (SHBG), and endometrial thickness were assessed before and after treatment. </p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Results:</span></strong> After 8 weeks, the FSFI score significantly improved in both groups. However, the change of FSFI score in the testosterone group was significantly higher than in the only estrogen group, 7.2 ± 5.5 and 4.6 ± 3.9, respectively (p ¼ 0.02). There were significantly increased serum total testosterone levels, but not the free or bioavailable form, in the testosterone group. There was no significant difference in serum SHBG levels after treatment between both groups. There was no serious adverse effect, only acne was found. </p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Conclusion: </span></strong>The addition of low-dose testosterone gel to daily estrogen may improve sexual function in postmenopausal women, but further evaluation and safety data are needed. </p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Conclusion </strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Although the addition of </span><span style="color: rgb(0, 0, 0)">weekly low-dose testosterone gel to daily estrogen</span><span style="color: rgb(184, 49, 47)"> may improve sexual function in postmenopausal women compared to estrogen only, further evaluation is needed because this study is underpowered. </span></strong>Additional study with a larger sample size is needed to confirm our findings, and a longer follow-up period is necessary for safety data.</p></blockquote><p></p>
[QUOTE="madman, post: 140257, member: 13851"] [B]Efficacy of oral estrogen plus testosterone gel to improve sexual function in postmenopausal women [/B] [B][COLOR=rgb(184, 49, 47)]S. Chaikittisilpa, K. Soimongkol & U. Jaisamrarn [/COLOR][/B] [B]ABSTRACT [/B] [B][COLOR=rgb(184, 49, 47)]Objective: [/COLOR][/B]This study aimed to study the efficacy and safety of estrogen plus low-dose testosterone gel in improving sexual function in postmenopausal women. [B][COLOR=rgb(184, 49, 47)]Methods:[/COLOR][/B] A double-blind, randomized, active-controlled trial was conducted. Seventy postmenopausal women with low sexual function were randomized into two groups. They received weekly 50 mg of transdermal testosterone plus daily oral 1 mg estradiol valerate or only estrogen for 8 weeks. The Female Sexual Function Index (FSFI) score, hematocrit, liver enzymes, lipid profiles, total testosterone, free and bioavailable testosterone, free androgen index, sex hormone binding globulin (SHBG), and endometrial thickness were assessed before and after treatment. [B][COLOR=rgb(184, 49, 47)]Results:[/COLOR][/B] After 8 weeks, the FSFI score significantly improved in both groups. However, the change of FSFI score in the testosterone group was significantly higher than in the only estrogen group, 7.2 ± 5.5 and 4.6 ± 3.9, respectively (p ¼ 0.02). There were significantly increased serum total testosterone levels, but not the free or bioavailable form, in the testosterone group. There was no significant difference in serum SHBG levels after treatment between both groups. There was no serious adverse effect, only acne was found. [B][COLOR=rgb(184, 49, 47)]Conclusion: [/COLOR][/B]The addition of low-dose testosterone gel to daily estrogen may improve sexual function in postmenopausal women, but further evaluation and safety data are needed. [B]Conclusion [/B] [B][COLOR=rgb(184, 49, 47)]Although the addition of [/COLOR][COLOR=rgb(0, 0, 0)]weekly low-dose testosterone gel to daily estrogen[/COLOR][COLOR=rgb(184, 49, 47)] may improve sexual function in postmenopausal women compared to estrogen only, further evaluation is needed because this study is underpowered. [/COLOR][/B]Additional study with a larger sample size is needed to confirm our findings, and a longer follow-up period is necessary for safety data. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
ExcelFemale
HRT in Women
Efficacy of oral estrogen plus testosterone gel to improve sexual function in postmenopausal women
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top