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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Efficacy of follitropin-alpha versus human menopausal gonadotropin
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<blockquote data-quote="madman" data-source="post: 168220" data-attributes="member: 13851"><p><strong>Efficacy of follitropin-alpha versus human menopausal gonadotropin for male patients with congenital hypogonadotropic hypogonadism </strong></p><p></p><p></p><p></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>ABSTRACT </strong></span></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>Objective:</strong></span> To compare human menopausal gonadotropin (hMG) and recombinant follicle-stimulating hormone (rFSH) with respect to successful spermatogenesis and pregnancy outcomes in patients with congenital hypogonadotropic hypogonadism (CHH).</p><p></p><p><strong>Material and methods:</strong> This retrospective study included a total of 112 male patients with CHH. Of these, 70 were to receive treatment with hMG and 42 with rFSH following the hCG administration.</p><p></p><p><strong>Results:</strong> The average age at diagnosis was 27.9 (range, 15–51) years. The baseline luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels were 0.53±0.77 IU/L, 0.63±0.61 IU/L, and 1.10±1.90 ng/dL, respectively. Following the combined hormonal treatment, 85.7% (96/112) of patients had sperm detected in ejaculate samples. In the hMG group, the mean baseline of a testicular size was slightly lower than in the rFSH group (5.0±3.5 mL and 5.3±3.9 mL), whereas these differences were not statistically significant (p=0.364). The mean baseline age, level of FSH, LH, and testosterone also showed no significant difference between the two treatment options. The rate of successful spermatogenesis was similar (85.7%) in both groups, while the pregnancy rates of patients who underwent hMG and rFSH treatments were 38.6% (n=27) and 51.2% (n=21); however, these differences were not statistically significant (p=0.314). No patients developed severe effects during the treatment period.</p><p></p><p><strong>Conclusion:</strong> <strong><span style="color: rgb(184, 49, 47)">Successful spermatogenesis and pregnancy rates with hMG and rFSH are similar </span></strong></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><span style="color: rgb(184, 49, 47)">In conclusion, the current medical approach for male patients with HH provides spermatogenesis successful enough for the achievement of pregnancy. <strong>The patients can achieve successful spermatogenesis via either rFSH or hMG</strong>,<strong> and there is no difference in outcomes between the two treatment regimes.</strong> </span><span style="color: rgb(44, 130, 201)"><strong>However, using urinary FSH may be a more cost-effective treatment option than the recombinant form</strong></span><strong>. </strong>Randomized controlled trials with greater patient numbers are required for future studies.</p></blockquote><p></p>
[QUOTE="madman, post: 168220, member: 13851"] [B]Efficacy of follitropin-alpha versus human menopausal gonadotropin for male patients with congenital hypogonadotropic hypogonadism [/B] [COLOR=rgb(184, 49, 47)][B]ABSTRACT [/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]Objective:[/B][/COLOR] To compare human menopausal gonadotropin (hMG) and recombinant follicle-stimulating hormone (rFSH) with respect to successful spermatogenesis and pregnancy outcomes in patients with congenital hypogonadotropic hypogonadism (CHH). [B]Material and methods:[/B] This retrospective study included a total of 112 male patients with CHH. Of these, 70 were to receive treatment with hMG and 42 with rFSH following the hCG administration. [B]Results:[/B] The average age at diagnosis was 27.9 (range, 15–51) years. The baseline luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels were 0.53±0.77 IU/L, 0.63±0.61 IU/L, and 1.10±1.90 ng/dL, respectively. Following the combined hormonal treatment, 85.7% (96/112) of patients had sperm detected in ejaculate samples. In the hMG group, the mean baseline of a testicular size was slightly lower than in the rFSH group (5.0±3.5 mL and 5.3±3.9 mL), whereas these differences were not statistically significant (p=0.364). The mean baseline age, level of FSH, LH, and testosterone also showed no significant difference between the two treatment options. The rate of successful spermatogenesis was similar (85.7%) in both groups, while the pregnancy rates of patients who underwent hMG and rFSH treatments were 38.6% (n=27) and 51.2% (n=21); however, these differences were not statistically significant (p=0.314). No patients developed severe effects during the treatment period. [B]Conclusion:[/B] [B][COLOR=rgb(184, 49, 47)]Successful spermatogenesis and pregnancy rates with hMG and rFSH are similar [/COLOR][/B] [COLOR=rgb(184, 49, 47)]In conclusion, the current medical approach for male patients with HH provides spermatogenesis successful enough for the achievement of pregnancy. [B]The patients can achieve successful spermatogenesis via either rFSH or hMG[/B],[B] and there is no difference in outcomes between the two treatment regimes.[/B] [/COLOR][COLOR=rgb(44, 130, 201)][B]However, using urinary FSH may be a more cost-effective treatment option than the recombinant form[/B][/COLOR][B]. [/B]Randomized controlled trials with greater patient numbers are required for future studies. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Efficacy of follitropin-alpha versus human menopausal gonadotropin
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