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General Health & Fitness
Nutrition and Supplements
Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis
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<blockquote data-quote="madman" data-source="post: 157004" data-attributes="member: 13851"><p>Creatine supplements are intended to improve performance, but there are indications that it can overwhelm liver and kidney functions, reduce the quality of life, and increase mortality. <span style="color: rgb(184, 49, 47)"><strong>Therefore, this is the first systematic review and meta-analysis study that aimed to investigate creatine supplements and their possible renal function side effects. After evaluating 290 non-duplicated studies, 15 were included in the qualitative analysis and 6 in the quantitative analysis. </strong></span><span style="color: rgb(44, 130, 201)"><strong>The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference 5 0.48, 95% confidence interval 0.24-0.73, P 5 .001, I 2 5 22%), </strong></span><span style="color: rgb(26, 188, 156)"><strong>and did not alter plasma urea values (standardized mean difference 5 1.10, 95% confidence interval 0.34-1.85, P 5 .004, I 2 5 28%).</strong></span> <strong>The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations. </strong></p><p></p><p></p><p></p><p></p><p>The objective of this systematic review and metaanalysis is to analyze the studies that verified the effects of creatine supplementation on renal function. <span style="color: rgb(184, 49, 47)"><strong>We conclude that most of the studies did not demonstrate renal damage with creatine supplementation; therefore, we are of the opinion that creatine supplements are safe for young adults and patients with chronic renal diseases. </strong></span>We suggest that further studies are needed that analyze the effects of creatine supplements in elderly patients with chronic renal failure and/or individuals with other pathologies. In addition, we emphasize the importance of more studies about quality control standards for dietary supplements.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Practical Application </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>The findings indicate that creatine supplementation does not induce renal damage. </strong></span><span style="color: rgb(44, 130, 201)"><strong>Thus, the creatine supplementation is relevant to clinicians in renal nutrition and/or working with population interested as athletes of strength and bodybuilding. </strong></span></p></blockquote><p></p>
[QUOTE="madman, post: 157004, member: 13851"] Creatine supplements are intended to improve performance, but there are indications that it can overwhelm liver and kidney functions, reduce the quality of life, and increase mortality. [COLOR=rgb(184, 49, 47)][B]Therefore, this is the first systematic review and meta-analysis study that aimed to investigate creatine supplements and their possible renal function side effects. After evaluating 290 non-duplicated studies, 15 were included in the qualitative analysis and 6 in the quantitative analysis. [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference 5 0.48, 95% confidence interval 0.24-0.73, P 5 .001, I 2 5 22%), [/B][/COLOR][COLOR=rgb(26, 188, 156)][B]and did not alter plasma urea values (standardized mean difference 5 1.10, 95% confidence interval 0.34-1.85, P 5 .004, I 2 5 28%).[/B][/COLOR] [B]The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations. [/B] The objective of this systematic review and metaanalysis is to analyze the studies that verified the effects of creatine supplementation on renal function. [COLOR=rgb(184, 49, 47)][B]We conclude that most of the studies did not demonstrate renal damage with creatine supplementation; therefore, we are of the opinion that creatine supplements are safe for young adults and patients with chronic renal diseases. [/B][/COLOR]We suggest that further studies are needed that analyze the effects of creatine supplements in elderly patients with chronic renal failure and/or individuals with other pathologies. In addition, we emphasize the importance of more studies about quality control standards for dietary supplements. [B]Practical Application [/B] [COLOR=rgb(184, 49, 47)][B]The findings indicate that creatine supplementation does not induce renal damage. [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]Thus, the creatine supplementation is relevant to clinicians in renal nutrition and/or working with population interested as athletes of strength and bodybuilding. [/B][/COLOR] [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis
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